Shimozawa K, Saisho S, Yata J, Kambegawa A
Department of Pediatrics, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Endocrinol Jpn. 1988 Apr;35(2):189-95. doi: 10.1507/endocrj1954.35.189.
In order to clarify some of the developmental processes of the human adrenal cortex or steroidogenesis in infancy and childhood, serum concentrations of 17-hydroxypregnenolone, 17-hydroxypregnenolone sulfate and 17-hydroxyprogesterone were measured by means of a combined radioimmunoassay method, and the age-related changes in these steroids were also examined. The actual ranges of serum concentrations of 17-hydroxypregnenolone, 17-hydroxypregnenolone sulfate and 17-hydroxyprogesterone in umbilical cord blood were 27.1-80.5, 1,560-5,030 and 53.3-304 nmol/l, respectively. These values subsequently decreased to nadirs of 0.95-2.09 nmol/l of 17-hydroxypregnenolone in subjects 1 to 2 years old, 0.93-7.03 nmool/l of 17-hydroxypregnenolone sulfate in subjects 3 to 6 years old and 0.18-0.78 nmol/l of 17-hydroxyprogesterone in subjects 1 to 2 years old, respectively, and they were followed by gradual increases to the adult levels. This study thus revealed the age-related changes in 17-hydroxypregnenolone and its sulfate concentrations in infancy and childhood and indicated that, in the process in which the adrenal cortex was differentiated to the definitive form, the decrease in the activity of steroid sulfotransferase in infancy and childhood occurred more slowly than the increase in that of 3 beta-hydroxysteroid dehydrogenase.
为了阐明人类肾上腺皮质在婴儿期和儿童期的一些发育过程或类固醇生成，采用联合放射免疫分析法测定了血清中17-羟孕烯醇酮、17-羟孕烯醇酮硫酸盐和17-羟孕酮的浓度，并研究了这些类固醇与年龄相关的变化。脐血中17-羟孕烯醇酮、17-羟孕烯醇酮硫酸盐和17-羟孕酮的血清浓度实际范围分别为27.1 - 80.5、1560 - 5030和53.3 - 304 nmol/L。这些值随后分别降至1 - 2岁儿童17-羟孕烯醇酮的最低点0.95 - 2.09 nmol/L、3 - 6岁儿童17-羟孕烯醇酮硫酸盐的最低点0.93 - 7.03 nmol/L和1 - 2岁儿童17-羟孕酮的最低点0.18 - 0.78 nmol/L，随后逐渐升高至成人水平。因此，本研究揭示了婴儿期和儿童期17-羟孕烯醇酮及其硫酸盐浓度与年龄相关的变化，并表明在肾上腺皮质分化为最终形式的过程中，婴儿期和儿童期类固醇硫酸转移酶活性的下降比3β-羟类固醇脱氢酶活性的增加更为缓慢。
