Alexiou George A, Vartholomatos George, Kobayashi Tatsuya, Voulgaris Spyridon, Kyritsis Athanasios P
Department of Neurosurgery, University Hospital of Ioannina, Greece; Neurosurgical Research Institute, University of Ioannina, Greece.
Neurosurgical Research Institute, University of Ioannina, Greece; Department of Hematology-Unit of Molecular Biology, University Hospital of Ioannina, Greece.
Clin Neurol Neurosurg. 2020 May;192:105742. doi: 10.1016/j.clineuro.2020.105742. Epub 2020 Feb 17.
Intraoperative flow cytometry has been recently emerged as a novel and promising tool for intracranial tumor surgery. Herewith, we discuss the role of intraoperative flow cytometry for the identification of gliomas boundaries, which may permit maximal resection and better prognosis. We also discuss its role in assessing tumor's grade of malignancy, both in adults and children and the prognostic information that may provide. Finally, intraoperative immunophenotypic analysis opens new horizons for flow cytometry. By evaluating tumor's specific cluster differentiation markers a diagnosis, within minutes, of certain tumor type can be achieved and additional information for therapeutic guidance can be provided.
术中流式细胞术最近已成为颅内肿瘤手术中一种新颖且有前景的工具。在此，我们讨论术中流式细胞术在识别胶质瘤边界方面的作用，这可能有助于实现最大程度的切除并获得更好的预后。我们还讨论其在评估成人和儿童肿瘤恶性程度以及可能提供的预后信息方面的作用。最后，术中免疫表型分析为流式细胞术开辟了新的视野。通过评估肿瘤的特定簇分化标志物，可以在几分钟内实现对某些肿瘤类型的诊断，并提供用于治疗指导的额外信息。
