King Abdullah Institute for Nanotechnology, King Saud University, Riyadh 11451, Saudi Arabia.
Department of Chemistry, King Saud University, Riyadh 11451, Saudi Arabia.
Colloids Surf B Biointerfaces. 2020 May;189:110877. doi: 10.1016/j.colsurfb.2020.110877. Epub 2020 Feb 14.
Neodymium hydroxide (Nd(OH))-surface modified mesoporous silica micro-cocoon microstructures were prepared using a facile single-step sol-gel chemical process. XRD revealed the semi-crystalline nature of the as-prepared materials. TEM and SEM micrographs exhibited highly monodisperse, non-aggregated, typical ordered mesoporous, and irregular sized cocoon-shaped micro-structures with a narrow size distribution. Optical properties, that were examined in the aqueous media, revealed a high colloidal stability and the formation of a semi-transparent colloidal solution. The colloidal solution of Nd(OH)-surface functionalized micro-structures revealed well characteristics absorption bands of Nd ions in the visible region. thus validating the successful coating of SiO@Nd(OH) layer over the surface silica forming core-shell structures. Zeta potential, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium) bromide, and neutral red uptake assays were applied in a dose-dependent manner to investigate the biocompatibility and toxic potential of the designed cocoon-shaped microstructures. Both the assays and the high zeta potential value demonstrated good cell viability even at high concentrations and hydrophilic conditions, indicating excellent biocompatibility and non-toxicity. These highly hydrophilic, optically active, mesoporous, biocompatible, and non-toxic cocoon-shaped microstructures could be potentially suitable candidates for optical bio-probes and drug delivery applications.
采用简便的一步溶胶-凝胶化学过程制备了钕氢氧化物（Nd(OH)）-表面修饰的介孔硅微茧微结构。XRD 显示出所制备材料的半晶态性质。TEM 和 SEM 显微照片显示出高度单分散、无聚集、典型有序介孔和不规则尺寸茧形微结构，具有较窄的尺寸分布。在水介质中检查的光学性质显示出高胶体稳定性和半透明胶体溶液的形成。Nd(OH)-表面功能化微结构的胶体溶液在可见区域显示出 Nd 离子的良好特征吸收带，从而验证了在形成核壳结构的表面硅上成功涂覆了 SiO@Nd(OH)层。Zeta 电位、3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴化物和中性红摄取测定以剂量依赖性方式应用于研究设计的茧形微结构的生物相容性和毒性潜力。两种测定方法和高 Zeta 电位值都证明了即使在高浓度和亲水条件下也具有良好的细胞活力，表明具有优异的生物相容性和非毒性。这些高亲水性、光学活性、介孔、生物相容性和非毒性的茧形微结构可能是光学生物探针和药物输送应用的潜在候选物。
