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p-fluoro-hexahydro-sila-difenidol: the first M2 beta-selective muscarinic antagonist.

作者信息

Lambrecht G, Feifel R, Forth B, Strohmann C, Tacke R, Mutschler E

机构信息

Department of Pharmacology, University of Frankfurt, Federal Republic of Germany.

出版信息

Eur J Pharmacol. 1988 Jul 26;152(1-2):193-4. doi: 10.1016/0014-2999(88)90856-4.

DOI:10.1016/0014-2999(88)90856-4
PMID:3208832
Abstract
摘要

相似文献

1
p-fluoro-hexahydro-sila-difenidol: the first M2 beta-selective muscarinic antagonist.
Eur J Pharmacol. 1988 Jul 26;152(1-2):193-4. doi: 10.1016/0014-2999(88)90856-4.
2
Affinity profiles of hexahydro-sila-difenidol analogues at muscarinic receptor subtypes.六氢硅二苯海拉明类似物在毒蕈碱受体亚型上的亲和力图谱。
Eur J Pharmacol. 1989 Sep 1;168(1):71-80. doi: 10.1016/0014-2999(89)90634-1.
3
Binding and functional properties of antimuscarinics of the hexocyclium/sila-hexocyclium and hexahydro-diphenidol/hexahydro-sila-diphenidol type to muscarinic receptor subtypes.六环铵/硅-六环铵和六氢双苯丙醇/六氢硅双苯丙醇型抗毒蕈碱药物与毒蕈碱受体亚型的结合及功能特性
Br J Pharmacol. 1989 Sep;98(1):197-205. doi: 10.1111/j.1476-5381.1989.tb16882.x.
4
Characterization of muscarinic receptors mediating vasodilation in rat perfused kidney.介导大鼠灌注肾血管舒张的毒蕈碱受体的特性研究
Eur J Pharmacol. 1993 Jul 20;238(2-3):343-55. doi: 10.1016/0014-2999(93)90866-g.
5
Stereoselective inhibition of muscarinic receptor subtypes by the enantiomers of hexahydro-difenidol and acetylenic analogues.六氢二苯醚及其乙炔类似物对映体对毒蕈碱受体亚型的立体选择性抑制作用。
Br J Pharmacol. 1990 Mar;99(3):455-60. doi: 10.1111/j.1476-5381.1990.tb12949.x.
6
Binding and functional properties of hexocyclium and sila-hexocyclium derivatives to muscarinic receptor subtypes.己环铵和硅己环铵衍生物与毒蕈碱受体亚型的结合及功能特性
Br J Pharmacol. 1994 Jun;112(2):505-14. doi: 10.1111/j.1476-5381.1994.tb13102.x.
7
Muscarinic receptor subtypes of guinea-pig gallbladder smooth muscle.豚鼠胆囊平滑肌的毒蕈碱受体亚型
Arch Int Pharmacodyn Ther. 1990 Nov-Dec;308:39-46.
8
Cyproheptadine displays high affinity for muscarinic receptors but does not discriminate between receptor subtypes.赛庚啶对毒蕈碱受体显示出高亲和力，但对受体亚型没有选择性。
Eur J Pharmacol. 1989 Dec 7;173(2-3):219-22. doi: 10.1016/0014-2999(89)90525-6.
9
Interaction of p-F-HHSiD (p-Fluoro-hexahydrosila-difenidol) at muscarinic receptors in guinea-pig trachea.对氟六氢硅二苯醚（p-Fluoro-hexahydrosila-difenidol）在豚鼠气管毒蕈碱受体上的相互作用
Naunyn Schmiedebergs Arch Pharmacol. 1990 Oct;342(4):394-9. doi: 10.1007/BF00169455.
10
o-Methoxy-sila-hexocyclium: a new quaternary M1-selective muscarinic antagonist.
Eur J Pharmacol. 1988 Jun 22;151(1):155-6. doi: 10.1016/0014-2999(88)90708-x.

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Pilocarpine modulates the cellular electrical properties of mammalian hearts by activating a cardiac M3 receptor and a K+ current.毛果芸香碱通过激活心脏M3受体和钾离子电流来调节哺乳动物心脏的细胞电特性。
Br J Pharmacol. 1999 Apr;126(8):1725-34. doi: 10.1038/sj.bjp.0702486.
2
Functional interactions between muscarinic M2 receptors and 5-hydroxytryptamine (5-HT)4 receptors and beta 3-adrenoceptors in isolated oesophageal muscularis mucosae of the rat.大鼠离体食管肌层黏膜中M2型毒蕈碱受体、5-羟色胺（5-HT）4受体与β3-肾上腺素能受体之间的功能相互作用
Br J Pharmacol. 1996 Oct;119(3):595-601. doi: 10.1111/j.1476-5381.1996.tb15714.x.
3
M1 and M3 muscarinic receptors in human pulmonary arteries.
人肺动脉中的M1和M3毒蕈碱受体。
Br J Pharmacol. 1996 Sep;119(1):149-57. doi: 10.1111/j.1476-5381.1996.tb15688.x.
4
Mucosa-dependent muscarinic liberation of prostaglandins from rat isolated trachea.大鼠离体气管中黏膜依赖性毒蕈碱介导的前列腺素释放
Br J Pharmacol. 1995 Oct;116(3):1991-8. doi: 10.1111/j.1476-5381.1995.tb16403.x.
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Characterization of muscarinic acetylcholine heteroreceptors modulating in vivo release of histamine in the rat hypothalamus.
Inflamm Res. 1995 Apr;44 Suppl 1:S58-9. doi: 10.1007/BF01674395.
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Interaction of selective compounds with muscarinic receptors at dispersed intestinal smooth muscle cells.选择性化合物与分散肠平滑肌细胞毒蕈碱受体的相互作用。
Br J Pharmacol. 1993 Feb;108(2):393-7. doi: 10.1111/j.1476-5381.1993.tb12815.x.
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Heterogeneity of muscarinic receptors in lamb isolated coronary resistance arteries.羔羊离体冠状动脉阻力动脉中毒蕈碱受体的异质性
Br J Pharmacol. 1993 Aug;109(4):998-1007. doi: 10.1111/j.1476-5381.1993.tb13720.x.
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Effects of indomethacin on muscarinic inhibition of endogenous noradrenaline release from rat isolated trachea.吲哚美辛对毒蕈碱抑制大鼠离体气管内源性去甲肾上腺素释放的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1993 Jul;348(1):21-7. doi: 10.1007/BF00168532.
9
Effects of muscarinic M2 and M3 receptor stimulation and antagonism on responses to isoprenaline of guinea-pig trachea in vitro.毒蕈碱M2和M3受体激动及拮抗对豚鼠离体气管对异丙肾上腺素反应的影响。
Br J Pharmacol. 1994 May;112(1):179-87. doi: 10.1111/j.1476-5381.1994.tb13049.x.
10
Different muscarinic receptor subtypes mediating the phasic activity and basal tone of pig isolated intravesical ureter.不同毒蕈碱受体亚型介导猪离体膀胱内输尿管的阶段性活动和基础张力。
Br J Pharmacol. 1993 Dec;110(4):1413-20. doi: 10.1111/j.1476-5381.1993.tb13978.x.