Smedmyr B, Killander A, Simonsson B, Sundström C
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
Eur J Haematol. 1988 Nov;41(5):478-81. doi: 10.1111/j.1600-0609.1988.tb00230.x.
20 consecutive adult patients with acute lymphoblastic leukemia were treated with an intense induction regimen including vincristine, doxorubicin, prednisolone, L-asparaginase and cyclophosphamide. 16 patients (80%) achieved complete remission and were then given CNS prophylaxis and 3 years of maintenance therapy. With minimum follow-up of 24 months, the median duration of first remission is 37+ months. Out of 10 patients who have completed maintenance therapy, 2 have relapsed after 14 and 22 months, respectively, and 7 are in continuous complete remission 1+-55+ months off therapy.
20例成年急性淋巴细胞白血病患者接受了强化诱导方案治疗，该方案包括长春新碱、阿霉素、泼尼松龙、L-天冬酰胺酶和环磷酰胺。16例患者（80%）获得完全缓解，随后接受中枢神经系统预防治疗及3年维持治疗。随访时间最短为24个月，首次缓解的中位持续时间为37 +个月。在10例完成维持治疗的患者中，分别有2例在14个月和22个月后复发，7例在停止治疗1 + - 55 +个月后持续完全缓解。
