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[二甲基膦酸对正常清醒家兔及运动病家兔脑血液循环和氧张力的影响]

[Effect of dimephosphon on the blood circulation and oxygen tension in the brain of normal waking rabbits and in motion sickness].

作者信息

Beketov A I, Skoromnyĭ N A

出版信息

Farmakol Toksikol. 1988 Sep-Oct;51(5):35-8.

PMID:3208883
Abstract

By using methods of hydrogen clearance and polarography it was shown that rocking of conscious rabbits is followed by an increase of total cerebral blood flow, local blood flow and oxygen tension (pO2) in the frontal, occipital and temporal brain cortex during hypotension and a decrease of the heart rate. Dimephosphon causes a decrease of the cerebral blood flow both during the stationary position of animals and rocking, exerting a weak influence on pO2 in the cerebral cortex, arterial blood pressure and the heart work.

摘要

通过使用氢清除法和极谱法表明,清醒家兔摇晃后,在低血压期间额叶、枕叶和颞叶脑皮质的总脑血流量、局部血流量和氧张力(pO₂)增加,心率降低。敌百虫在动物静止和摇晃期间均导致脑血流量减少,对脑皮质中的pO₂、动脉血压和心脏活动影响较弱。

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