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局部麻醉药的不良反应:总是过敏反应吗?

Adverse reaction to local anaesthetics: Is it always allergy?

作者信息

Furci Fabiana, Martina Stefano, Faccioni Paolo, Faccioni Fiorenzo, Senna Gianenrico, Caminati Marco

机构信息

Allergy and Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University Hospital G. Martino, University of Messina, Messina, Italy.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.

出版信息

Oral Dis. 2020 Sep;26(6):1340-1342. doi: 10.1111/odi.13310. Epub 2020 Mar 11.

Abstract

OBJECTIVE

Local anaesthetics are very commonly used drugs in dentistry, and people who undergo procedures with local anaesthetics often refer adverse reactions that are not of allergic origin. Considering that in dentistry contact with allergens is very frequent, it is essential to assess the real incidence of allergy to local anaesthetics.

SUBJECTS AND METHODS

We evaluated a group of 159 patients in whom adverse reaction occurred after procedures with local anaesthetics.

RESULTS

The reactions between allergy to local anaesthetic (immediate and delayed) and certain symptoms presented by patients were investigated. Allergy to latex and chlorexidine were investigated in all patients. Only one patient, who previously presented a constant erythema at the wrist after procedure with local anaesthetics, was positive to Mepivacaine patch test. Two patients were positive to latex and one to chlorexidine.

CONCLUSIONS

The main finding of this study was that a reaction registered in the medical history and reported by a patient is rarely allergic but the use of vasoconstrictors or emotional factors may account for it. However, a complete allergological investigation is necessary for a correct diagnosis and future management.

摘要

目的

局部麻醉剂是牙科领域非常常用的药物,接受局部麻醉手术的患者经常提及并非由过敏引起的不良反应。鉴于在牙科领域接触过敏原的情况非常频繁,评估对局部麻醉剂过敏的实际发生率至关重要。

研究对象与方法

我们评估了一组159例在接受局部麻醉手术后出现不良反应的患者。

结果

对局部麻醉剂过敏(即刻和延迟过敏)与患者出现的某些症状之间的反应进行了调查。对所有患者进行了乳胶和洗必泰过敏调查。只有一名患者在接受局部麻醉手术后手腕处持续出现红斑,对甲哌卡因斑贴试验呈阳性。两名患者对乳胶呈阳性,一名对洗必泰呈阳性。

结论

本研究的主要发现是,病历中记录并由患者报告的反应很少是过敏反应,但使用血管收缩剂或情绪因素可能是其原因。然而,为了正确诊断和未来的治疗管理,进行全面的变态反应学调查是必要的。

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