2017 年从韩国分离的立克次体物种的分子遗传学分析和临床特征。
Molecular genetic analysis and clinical characterization of Rickettsia species isolated from the Republic of Korea in 2017.
机构信息
Department of Infectious Diseases, Chungnam National University Hospital, Daejeon, Korea.
Department of Microbiology, Konkuk University School of Medicine, Seoul, Korea.
出版信息
Transbound Emerg Dis. 2020 Jul;67(4):1447-1452. doi: 10.1111/tbed.13525. Epub 2020 Mar 6.
Rickettsia sp. CNH17-7 was isolated from patients' blood and identified by gene analysis as a species distinct from Rickettsia japonica. In addition, similar rickettsial infection was confirmed in two species (Haemaphysalis longicornis and Ixodes nipponensis) of ticks and rodents in northeastern and southwestern provinces, Republic of Korea. Subsequently, the analysis of 16S rRNA, ompA, ompB and sca4 genes of isolate CNH17-7 revealed 100%, 99.68%, 99.57% and 99.44% sequence similarity with Rickettsia sp. HlR/D91 and Candidatus R. longicornii ROK-HL727. In this study, we report the isolation of a new Rickettsia sp. CNH17-7 and infection of different types of ticks with the same rickettsial agents.
从患者血液中分离出的 Rickettsia sp. CNH17-7 通过基因分析鉴定为不同于 Rickettsia japonica 的物种。此外，在韩国东北部和西南部省份的两种蜱（长角血蜱和日本革蜱）和啮齿动物中也确认了类似的立克次体感染。随后，对分离株 CNH17-7 的 16S rRNA、ompA、ompB 和 sca4 基因分析显示，其与 Rickettsia sp. HlR/D91 和 Candidatus R. longicornii ROK-HL727 的序列相似度分别为 100%、99.68%、99.57%和 99.44%。本研究报告了一种新的 Rickettsia sp. CNH17-7 的分离和不同类型蜱携带相同立克次体的感染。
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