Sellers T A, Elston R C, Stewart C, Rothschild H
Department of Medicine, Louisiana State University, New Orleans.
Genet Epidemiol. 1988;5(6):381-91. doi: 10.1002/gepi.1370050603.
Several investigators have reported that relatives of lung cancer probands have a greater-than-normal likelihood for developing some form of cancer. To evaluate whether this familial risk is general for probands with cancer at any site or limited to lung cancer probands, we did a case-control study in which probands having cancer affecting any body site were identified and their pedigree data were tabulated. Telephone interviews and a mailed questionnaire were used to obtain cancer histories and environmental exposures on the families of 41 lung cancer probands, 105 probands with cancer other than lung, and 127 spouse families. Cumulative tobacco exposure (P less than .05), occupational hazards (P less than .005), and age of the family relatives (P less than .0001) were found to be statistically significant predictors of cancer risk. With consideration given for these variables, we determined that siblings of lung cancer probands were at slightly greater risk of cancer of any kind (odds ratio [OR] = 1.43, P = .06) than siblings in the control group. Much of the elevated risk was attributable to an excess of lung cancer (OR = 2.49, P = .06). Siblings of non-lung/non-breast cancer probands were also determined to be at increased risk of lung cancer as well (OR = 1.61, P = .06). For parents, the risk was lower, although parental information may have been underreported.
几位研究人员报告称，肺癌先证者的亲属患某种癌症的可能性高于正常水平。为了评估这种家族性风险是适用于任何部位患癌的先证者，还是仅限于肺癌先证者，我们进行了一项病例对照研究，确定了身体任何部位患癌的先证者，并将他们的谱系数据制成表格。通过电话访谈和邮寄问卷的方式，获取了41名肺癌先证者、105名非肺癌癌症先证者以及127个配偶家庭的癌症病史和环境暴露情况。发现累积烟草暴露（P<0.05）、职业危害（P<0.005）以及家族亲属的年龄（P<0.0001）是癌症风险的统计学显著预测因素。考虑到这些变量，我们确定肺癌先证者的兄弟姐妹患任何类型癌症的风险（优势比[OR]=1.43，P=0.06）略高于对照组的兄弟姐妹。风险升高在很大程度上归因于肺癌过多（OR=2.49，P=0.06）。非肺癌/非乳腺癌先证者的兄弟姐妹患肺癌的风险也被确定有所增加（OR=1.61，P=0.06）。对于父母来说，风险较低，尽管父母的信息可能报告不足。
