Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, The Broad Institute of Harvard and MIT, Cambridge, MA, USA; Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA.
J Affect Disord. 2020 Mar 15;265:255-262. doi: 10.1016/j.jad.2020.01.005. Epub 2020 Jan 7.
Low maternal vitamin D levels [serum 25-hydroxyvitamin D (25(OH)D)] during pregnancy have been linked to offspring neuropsychiatric outcomes such as schizophrenia and autism, but studies on depression are lacking. We examined the association between maternal vitamin D status during pregnancy and offspring depression during childhood and adolescence and investigated whether any associations were modified by offspring genetic risk for depression.
Mother-singleton birth offspring pairs in the Avon Longitudinal Study of Parents and Children (ALSPAC) that had maternal 25(OH)D measurements, offspring genetic data, and offspring depression measures collected in childhood (mean age=10.6 years; n = 2938) and/or adolescence (mean age=13.8 years; n = 2485) were included in the analyses. Using multivariable logistic regression, we assessed associations between maternal vitamin D status and offspring polygenic risk score (PRS) for depression on childhood/adolescent depression risk.
There was no evidence for an association between maternal vitamin D status during pregnancy and offspring depression in childhood (p = 0.72) or adolescence (p = 0.07). Offspring depression PRS were independently associated with childhood depression (p = 0.003), but did not interact with maternal vitamin D status. These results were robust to adjustments for potential confounders and different cut-offs for vitamin D insufficiency/deficiency.
25(OH)D measurements were only available at a single time point during pregnancy.
These findings suggest that maternal vitamin D status during pregnancy does not affect an offspring's risk for early life depression.
孕妇维生素 D 水平低（血清 25-羟维生素 D（25(OH)D））与后代神经精神结局有关，如精神分裂症和自闭症，但关于抑郁症的研究较少。我们研究了孕妇维生素 D 状态与后代儿童和青少年期抑郁症之间的关系，并探讨了后代抑郁的遗传风险是否改变了这种关联。
纳入了阿冯纵向父母和儿童研究（ALSPAC）中具有母亲 25(OH)D 测量值、后代遗传数据和儿童期（平均年龄=10.6 岁；n=2938）和/或青春期（平均年龄=13.8 岁；n=2485）收集后代抑郁症测量值的母子单胎出生后代对。我们使用多变量逻辑回归，评估了母亲怀孕期间维生素 D 状态与后代抑郁多基因风险评分（PRS）与儿童/青少年抑郁风险之间的关联。
孕妇怀孕期间维生素 D 状态与儿童期（p=0.72）或青春期（p=0.07）后代抑郁症之间没有证据表明存在关联。后代抑郁 PRS 与儿童期抑郁症独立相关（p=0.003），但与母亲维生素 D 状态无交互作用。这些结果在调整潜在混杂因素和不同维生素 D 不足/缺乏的截止值后仍然稳健。
25(OH)D 测量仅在怀孕期间的单一时间点进行。
这些发现表明，孕妇怀孕期间的维生素 D 状态不会影响后代早期生活中患抑郁症的风险。
