大鼠胸腺内亲金属巨噬细胞的产后发育。
Postnatal development of metallophilic macrophages in the rat thymus.
机构信息
Faculty of Medicine, Institute of Histology and Embryology, University of Belgrade, Belgrade, Serbia.
Department for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
出版信息
Anat Histol Embryol. 2020 Jul;49(4):433-439. doi: 10.1111/ahe.12545. Epub 2020 Feb 24.
Metallophilic macrophages (MMs) are a distinct cell type of the rodent thymus. Our previous research has focused on the morphological characteristics of MMs, as well as on the molecular mechanisms involved in the development and tissue positioning of these cells. However, the postnatal development of MMs has not been sufficiently studied. In the present study, we investigated the positioning of MMs in the rat thymus between postnatal day 0 (P0) and P30. On P0, MMs were evenly distributed all over the thymic tissue-that is, the cortex, cortico-medullary zone and medulla. From P0 to P15, the number of MMs in the thymic cortex significantly decreased, and after P15, this number did not change. Thus, the present study shows that on P15, MMs almost completely disappear from the thymic cortex and show their adult position in the cortico-medullary zone and in the medulla.
亲金属巨噬细胞（MMs）是啮齿动物胸腺中一种独特的细胞类型。我们之前的研究重点是 MMs 的形态特征，以及这些细胞的发育和组织定位所涉及的分子机制。然而，MMs 的出生后发育尚未得到充分研究。在本研究中，我们研究了大鼠胸腺中 MMs 在出生后第 0 天（P0）至 P30 之间的定位。在 P0 时，MMs 均匀分布于整个胸腺组织，即皮质、皮质-髓质区和髓质。从 P0 到 P15，胸腺皮质中的 MMs 数量显著减少，P15 后，这一数量不再变化。因此，本研究表明，在 P15 时，MMs 几乎完全从胸腺皮质中消失，并在皮质-髓质区和髓质中呈现其成年位置。
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