瘙痒性和非瘙痒性血液透析患者的皮肤肥大细胞数量

Cutaneous mast cell quantity in pruritic and nonpruritic hemodialysis patients.

作者信息

Klein L R, Klein J B, Hanno R, Callen J P

机构信息

Department of Medicine, University of Louisville School of Medicine, Kentucky.

出版信息

Int J Dermatol. 1988 Oct;27(8):557-9. doi: 10.1111/j.1365-4362.1988.tb02404.x.

DOI:10.1111/j.1365-4362.1988.tb02404.x

PMID:3209316

Abstract

Pruritus remains a significant complication of end-stage renal disease. Its cause in hemodialysis patients is not known. It has been postulated that increased numbers of mast cells occur in these patients and may account for the presence of pruritus. Our objective was to determine if there is a difference in the number of cutaneous mast cells between pruritic and nonpruritic patients. A 3-mm punch biopsy specimen was obtained from pruritic (n = 7) and nonpruritic (n = 6) hemodialysis patients. We observed no significant difference in the quantity of cutaneous mast cells in pruritic and nonpruritic hemodialysis patients. We conclude that the etiology of pruritus in hemodialysis patients is not related to an increase in the number of cutaneous mast cells.

摘要

瘙痒仍然是终末期肾病的一个重要并发症。其在血液透析患者中的病因尚不清楚。据推测，这些患者体内肥大细胞数量增加，可能是瘙痒存在的原因。我们的目的是确定瘙痒患者与无瘙痒患者之间皮肤肥大细胞数量是否存在差异。从瘙痒的血液透析患者（n = 7）和无瘙痒的血液透析患者（n = 6）中获取3毫米的打孔活检标本。我们观察到瘙痒和无瘙痒的血液透析患者皮肤肥大细胞数量没有显著差异。我们得出结论，血液透析患者瘙痒的病因与皮肤肥大细胞数量增加无关。