Boiron P, Provost F
Institut Pasteur, Unité de Mycologie, Paris, France.
J Antimicrob Chemother. 1988 Nov;22(5):623-9. doi: 10.1093/jac/22.5.623.
By disc diffusion, 28 clinical isolates of four species of Nocardia were tested against 16 antimicrobial agents. Among the drugs included in the study, only a few exhibited in-vitro activities. A species difference in susceptibility was noted for amoxicillin + clavulanic acid, kanamycin, gentamicin, chloramphenicol, minocycline and erythromycin, which was of clinical and taxonomic interest. All six N. brasiliensis and six N. otitidis-caviarum were susceptible to gentamicin and minocycline, while all 15 N. asteroides were not. In addition, N. otitidis-caviarum was susceptible to kanamycin and chloramphenicol, while the sensitivity of N. farcinica was less predictable. The only antibiotic to which members of all of the Nocardia species tested were susceptible was amikacin, which therefore appears to be a good candidate for the treatment of all forms of nocardial infections.
采用纸片扩散法，对28株4种诺卡菌临床分离株进行了16种抗菌药物的药敏试验。在本研究纳入的药物中，只有少数药物表现出体外活性。阿莫西林+克拉维酸、卡那霉素、庆大霉素、氯霉素、米诺环素和红霉素的药敏存在种间差异，这具有临床和分类学意义。所有6株巴西诺卡菌和6株耳腔诺卡菌对庆大霉素和米诺环素敏感，而所有15株星型诺卡菌均不敏感。此外，耳腔诺卡菌对卡那霉素和氯霉素敏感，而豚鼠耳炎诺卡菌的敏感性较难预测。所有受试诺卡菌种的成员均敏感的唯一抗生素是阿米卡星，因此它似乎是治疗各种诺卡菌感染的良好候选药物。
