Takahashi Natsuko, Okumura Yoshiyuki, Sawaragi Eiichi
Department of Plastic and Reconstructive Surgery, Japanese Red Cross Society Wakayama Medical Center, Wakayama-Shi, Wakayama, Japan.
Plast Reconstr Surg Glob Open. 2020 Jan 20;8(1):e2602. doi: 10.1097/GOX.0000000000002602. eCollection 2020 Jan.
An 83-year-old Japanese man who had been aware of a tumor near his anus for 2 years underwent tumor resection. Although he was diagnosed with basal cell carcinoma (BCC), extramammary Paget disease (EMPD) was also accidentally found in the same specimen. In the pathological histology of EMPD, there were large round cells with ample cytoplasm spread in the epidermis; these cells were positive for cytokeratin 7 and gross cystic disease fluid protein 15. No signs that are typically associated with EMPD, such as erythema or leukoderma, were observed near the anus. There have been only 4 reports in which BCC and EMPD developed in the same area, and the authors present the fifth case. In the reported case, no clear evidence was found for the corelative development of BCC and EMPD.
一名83岁的日本男性，意识到肛门附近有肿瘤2年，随后接受了肿瘤切除手术。尽管他被诊断为基底细胞癌（BCC），但在同一标本中还意外发现了乳腺外佩吉特病（EMPD）。在EMPD的病理组织学中，表皮中有大量细胞质丰富的大圆形细胞；这些细胞细胞角蛋白7和总囊性病液蛋白15呈阳性。在肛门附近未观察到通常与EMPD相关的体征，如红斑或白斑。仅有4篇报告指出BCC和EMPD在同一区域发生，本文作者报告了第5例。在所报告的病例中，未发现BCC和EMPD相关发展的确切证据。
