Wilson J, Merwin G E
J. Hillis Miller Health Center, University of Florida, Gainesville 32610.
J Biomed Mater Res. 1988 Aug;22(A2 Suppl):159-77. doi: 10.1002/jbm.820221308.
Presently no material is available which is entirely satisfactory for facial bone augmentation. These studies examine several of those already in clinical use, made from various polymers in solid, porous, and woven forms. Homograft bone has also been studied, as an implant material. All materials were used in situations for which they are currently recommended clinically. Bioglass (Bioglass is a trademark of the University of Florida) implants, which are suggested for clinical use, have been studied in the same model and results show that their surface activity provides a more satisfactory immobilization, both in the short and long term, than does the tissue ingrowth on which most of the other materials depend. Results show that in this model as well as in clinical practice, porous and woven materials provoke in tissues a continuing cellular response which will always compromise long-term clinical success. Autograft bone has associated morbidity and is unpredictable with respect to its incorporation into host tissue and persistence at the site. Bioglass, however, was immobilized successfully at both hard and soft tissue interfaces without the need for porosity, could be satisfactorily shaped in the operating room, and, in addition, had the bonelike hardness which is not provided by any other available material.
目前尚无完全令人满意的用于面部骨增量的材料。这些研究考察了几种已在临床使用的材料，它们由各种聚合物制成，有固体、多孔和编织形式。同种异体骨作为一种植入材料也已被研究。所有材料都用于目前临床推荐的适用情况。临床建议使用的生物玻璃（生物玻璃是佛罗里达大学的商标）植入物，已在同一模型中进行了研究，结果表明，与大多数其他材料所依赖的组织长入相比，其表面活性在短期和长期都能提供更令人满意的固定效果。结果表明，在该模型以及临床实践中，多孔和编织材料会在组织中引发持续的细胞反应，这将始终影响长期临床效果。自体骨存在相关的发病率，并且在其融入宿主组织以及在该部位的存留方面不可预测。然而，生物玻璃在硬组织和软组织界面均成功固定，无需孔隙结构，在手术室中可令人满意地塑形，此外，还具有其他现有材料所不具备的骨样硬度。
