tau 寡聚物。
Tau Oligomers.
机构信息
Department of Physiology, Keio University School of Medicine, Tokyo, Japan.
Department of Life Science, Gakushuin University, Tokyo, Japan.
出版信息
Adv Exp Med Biol. 2019;1184:373-380. doi: 10.1007/978-981-32-9358-8_27.
The accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including Alzheimer's disease. However, it is not the filamentous aggregates themselves, but non-filamentous tau species, tau oligomer, that is thought to be the culprit in tau-mediated neurodegeneration. The definition of and methodology for isolating tau oligomers vary among researchers. Here we describe how tau oligomers are identified, summarize the differences of tau oligomers among research groups, and discuss their hypothesized functions.
tau 纤维在神经元中的积累是各种神经退行性疾病的病理标志，包括阿尔茨海默病。然而，被认为是 tau 介导的神经退行性变罪魁祸首的不是丝状聚集体本身，而是无纤维 tau 物种，tau 寡聚物。tau 寡聚物的定义和分离方法在研究人员之间存在差异。在这里，我们描述了 tau 寡聚物的鉴定方法，总结了不同研究组之间 tau 寡聚物的差异，并讨论了它们的假设功能。
Zotero 插件