Henry J F, Denizot A, Audiffret J, France G
Service de Chirurgie Générale, Centre Hospitalo-Universitaire de la Timone, Marseille.
J Chir (Paris). 1988 Jun-Jul;125(6-7):395-400.
Results are reported of surgical treatment of hyperparathyroidism secondary to chronic renal failure in 231 patients who had undergone 250 operations over 16 years: 152 total parathyroidectomies associated in 151 cases with an autotransplant, 58 subtotal parathyroidectomies, 9 incomplete parathyroidectomies, I white cervicotomy and 39 repeat operations for persistent or recurrent hyperparathyroidism. Results were evaluated clinically, biologically and radiologically after a mean follow up of 4 years, and were rated good in 71.4% of cases. The quality of the results was independent of the type of parathyroidectomy practised: 71% good results after total parathyroidectomy with autotransplantation and 69% after subtotal parathyroidectomy. No significant difference was demonstrated between the two techniques with respect to mortality, postoperative morbidity and late complications. The only divergence seen was in relation to recurrences: recovery surgery at the cervical level after subtotal parathyroidectomy leaving a clearly identified glandular stump associated with a better result than repeat operation on grafts at brachial level after total parathyroidectomy and autograft. These results led to the adoption of a surgical routine for hyperparathyroidism secondary to chronic renal failure using subtotal parathyroidectomy combined with bilateral thymectomy. The operation of total parathyroidectomy without immediate autotransplant is reserved for cervical recovery surgical procedures. Whatever the technique used, frozen storage of removed tissue is the indispensable complement of parathyroidectomy.
报告了16年间对231例慢性肾衰竭继发性甲状旁腺功能亢进患者进行250次手术的治疗结果:152例甲状旁腺全切术,其中151例伴有自体移植;58例次全甲状旁腺切除术;9例不完全甲状旁腺切除术;1例颈部探查术;39例因持续性或复发性甲状旁腺功能亢进而进行的再次手术。平均随访4年后,从临床、生物学和放射学方面对结果进行评估,71.4%的病例结果评定为良好。结果的质量与所施行的甲状旁腺切除术类型无关:甲状旁腺全切并自体移植术后71%结果良好,次全甲状旁腺切除术后69%结果良好。两种技术在死亡率、术后发病率和晚期并发症方面无显著差异。唯一的不同在于复发情况:次全甲状旁腺切除术后在颈部进行修复手术,保留明确的腺体残端,其结果优于甲状旁腺全切并自体移植术后在臂部对移植体进行再次手术。这些结果促使采用一种针对慢性肾衰竭继发性甲状旁腺功能亢进的手术常规方法,即次全甲状旁腺切除术联合双侧胸腺切除术。不立即进行自体移植的甲状旁腺全切术则保留用于颈部修复手术。无论采用何种技术,切除组织的冷冻保存都是甲状旁腺切除术必不可少的补充。