Department of Veterinary Pathology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
These authors contributed equally to this work.
Vet Pathol. 2020 May;57(3):418-426. doi: 10.1177/0300985820906891. Epub 2020 Feb 25.
This is a histopathologic and endocrinologic study of 6 calves diagnosed with cryptorchidism. Cases 1-3 were diagnosed as resembling testicular regression syndrome. In cases 1 and 2, the extracted tissue was a small, firm, gray-white mass, and there was lack of obvious testicular tissue in case 3. Histopathologically, the excised tissue in cases 1-3 was a fibrotic testicular remnant with inflammation, mineralization, hemosiderin-laden macrophages or lipofuscin-laden macrophages, and lack of germ cells and interstitial endocrine cells. These findings were compared with cases 4-6, which were diagnosed as testicular hypoplasia due to cryptorchidism. These cases had small but otherwise grossly unremarkable intra-abdominal testicular tissue and histologically had a few germ cells and sustentacular cells with arrested spermatogenesis and an increase in interstitial endocrine cells. Cases 1-3 had more severe degenerative changes compared with cases 4-6. In case 2, the average diameter of the seminiferous tubules was much smaller than in cases 4-6, and there were few tubule cross sections. Anti-Müllerian hormone (214 pg/ml) was detected in the plasma of case 2. Based on the macroscopic and histopathologic findings as well as endocrinologic profiles, the testicular degeneration in cases 1-3 was considered similar to that of testicular regression syndrome. In this condition, it is thought that a normally developing intra-abdominal testis undergoes degeneration due to heat or a vascular disorder such as torsion.
这是对 6 头诊断为隐睾的小牛进行的组织病理学和内分泌学研究。病例 1-3 被诊断为类似于睾丸退化综合征。在病例 1 和 2 中，提取的组织是一个小而坚硬的灰白色肿块，而病例 3 中则缺乏明显的睾丸组织。组织病理学上，病例 1-3 切除的组织是纤维化的睾丸残余组织，伴有炎症、矿化、含铁血黄素或脂褐素的巨噬细胞，以及缺乏生殖细胞和间质内分泌细胞。这些发现与病例 4-6 进行了比较，这些病例被诊断为隐睾引起的睾丸发育不全。这些病例的腹腔内睾丸组织虽然较小，但大体上无明显异常，组织学上有少量生殖细胞和支持细胞，伴有生精停滞和间质内分泌细胞增多。病例 1-3 与病例 4-6 相比，退行性变化更为严重。在病例 2 中，生精小管的平均直径比病例 4-6 小得多，而且小管横截面积较少。在病例 2 的血浆中检测到抗苗勒管激素（214pg/ml）。根据大体和组织病理学发现以及内分泌谱，病例 1-3 的睾丸退行性变被认为类似于睾丸退化综合征。在这种情况下，人们认为正常发育的腹腔内睾丸由于热或血管紊乱（如扭转）而发生退化。
