Ranta R
Department of Pedodontics and Orthodontics, University of Helsinki, Finland.
J Craniofac Genet Dev Biol. 1988;8(3):245-51.
Variations in tooth number in children, each of whom had supernumerary teeth and agenesis of teeth, is described. Among the 11, seven had cleft lip and palate, and two had clefting syndromes; two children had dental anomalies only. Only children who had both supernumerary teeth and congenitally missing teeth outside the area of the cleft alveolus were included. Concomitant hypodontia and hyperdontia were observed in the same dentition in nine subjects, in the same jaw in eight subjects, and in the same jaw quadrant in only three subjects. Supernumerary teeth and agenesis of teeth were observed simultaneously more often in the permanent dentitions than in the deciduous dentitions or in both dentitions simultaneously. The overall number of supernumeraries was 10 in the deciduous dentition and 14 in the permanent dentition of the 11 subjects. The number of congenitally absent teeth was 14 in the deciduous dentition and 40 in the permanent dentition. The etiology of concomitant hypodontia and hyperdontia is difficult to explain. It may result from disturbances in migration, proliferation, and differentiation of neural crest cells or interactions between the epithelial and mesenchymal cells during the initiation of odontogenesis.
描述了患有多生牙和牙齿缺失的儿童的牙齿数量变化情况。在这11名儿童中，7名患有唇腭裂，2名患有腭裂综合征；2名儿童仅有牙齿异常。仅纳入了在牙槽裂区域以外同时有多生牙和先天性缺牙的儿童。9名受试者在同一牙列中观察到伴随的缺牙症和多生牙症，8名受试者在同一颌骨中观察到，仅3名受试者在同一颌骨象限中观察到。多生牙和牙齿缺失在恒牙列中同时出现的情况比在乳牙列中或在两个牙列中同时出现的情况更常见。在这11名受试者的乳牙列中，多生牙的总数为10颗，恒牙列中为14颗。先天性缺牙的数量在乳牙列中为14颗，恒牙列中为40颗。伴随的缺牙症和多生牙症的病因难以解释。它可能是由于神经嵴细胞迁移、增殖和分化过程中的干扰，或者是牙胚发生起始过程中上皮细胞和间充质细胞之间的相互作用所致。
