From the U.O.C. Multidisciplinare di Senologia, Azienda Ospedaliera Cannizzaro Catania; Chi.Pla Chirurgia Plastica (private practice); Department of Biomedical and Biotechnological Sciences, University of Catania; IRCCS Centro Neurolesi Bonino-Pulejo; and Department of Medical and Surgical Sciences and Advanced Technologies, G.F. Ingrassia, Anatomic Pathology Section, University of Catania.
Catania and Messina, Italy.
Plast Reconstr Surg. 2020 Mar;145(3):701-710. doi: 10.1097/PRS.0000000000006553.
One of the most common complications of the use of foreign material, in both reconstructive and cosmetic breast surgery, is capsular contracture. Historically, research on capsular contracture has focused mainly on reducing bacterial contamination through antibiotic solutions. Only secondary studies have focused on pharmacological control of the inflammation process, with particular attention paid to the main inflammation pathway, the arachidonic acid cascade. An important role in the arachidonic acid cascade is played by the omega-3 fatty acids, which are found mainly in oily fish and food supplements. The goal of the present study was to investigate the effects of omega-3 supplements on capsule contraction.
Female C57BL/6 mice were implanted with custom-made silicone gel implants and divided into two groups. The treated group received omega-3 oil daily while the control group received water daily by gavage. After mice were euthanized, samples of capsules were collected to evaluate thickness and transforming growth factor (TGF)-β expression.
The results showed that capsules in the omega-3 group were thinner and more transparent than those found in the control group. In addition, a significant downregulation of the TGF-β2 gene transcript was observed in the omega-3 group.
Omega-3 supplementation seems to be effective in reducing the occurrence of capsular formation, mainly through inhibition of the TGF-β pathway and impairment of collagen deposit. Omega-3 supplementation is a simple and promising method that could be used to prevent or at least reduce capsular contracture after silicone implant surgery.
在重建和美容乳房手术中外来材料的使用最常见的并发症之一是包膜挛缩。历史上，对包膜挛缩的研究主要集中在通过抗生素溶液减少细菌污染。只有次要研究集中在炎症过程的药理学控制上，特别关注主要的炎症途径，即花生四烯酸级联。ω-3 脂肪酸在花生四烯酸级联中起着重要作用，主要存在于油性鱼类和食品补充剂中。本研究的目的是研究 ω-3 补充剂对胶囊收缩的影响。
将雌性 C57BL/6 小鼠植入定制的硅胶凝胶植入物，并分为两组。治疗组每天接受 ω-3 油，而对照组每天通过灌胃接受水。处死小鼠后，收集胶囊样本以评估厚度和转化生长因子 (TGF)-β表达。
结果表明，ω-3 组的胶囊比对照组的胶囊更薄、更透明。此外，在 ω-3 组中观察到 TGF-β2 基因转录物的显著下调。
ω-3 补充似乎可有效减少包膜形成的发生，主要通过抑制 TGF-β 途径和损害胶原蛋白沉积。ω-3 补充是一种简单且有前途的方法，可用于预防或至少减少硅胶植入手术后的包膜挛缩。
