Commentary: Using human genetics to guide the repurposing of medicines.
作者信息
Bovijn Jonas, Censin Jenny C, Lindgren Cecilia M, Holmes Michael V
机构信息
Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
出版信息
Int J Epidemiol. 2020 Aug 1;49(4):1140-1146. doi: 10.1093/ije/dyaa015.
Abstract
摘要
相似文献
1
Commentary: Using human genetics to guide the repurposing of medicines.评论：利用人类遗传学指导药物的重新利用。
Int J Epidemiol. 2020 Aug 1;49(4):1140-1146. doi: 10.1093/ije/dyaa015.
2
Repurposing antihypertensive drugs for the prevention of Alzheimer's disease: a Mendelian randomization study.将降压药物重新用于预防阿尔茨海默病：一项孟德尔随机化研究。
Int J Epidemiol. 2020 Aug 1;49(4):1132-1140. doi: 10.1093/ije/dyz155.
3
The Potential of Genetic Data for Prioritizing Drug Repurposing Efforts.基因数据在确定药物重新利用工作优先级方面的潜力。
Neurology. 2022 Aug 16;99(7):267-268. doi: 10.1212/WNL.0000000000200803. Epub 2022 Jun 2.
4
Antihypertensive Drugs for the Prevention of Atrial Fibrillation: A Drug Target Mendelian Randomization Study.用于预防心房颤动的抗高血压药物：一项药物靶点孟德尔随机化研究
Hypertension. 2024 Aug;81(8):1766-1775. doi: 10.1161/HYPERTENSIONAHA.123.21858. Epub 2024 Jun 19.
5
Repurposing Antihypertensive Drugs for the Prevention of Glaucoma: A Mendelian Randomization Study.抗高血压药物在青光眼预防中的再利用：孟德尔随机化研究。
Transl Vis Sci Technol. 2022 Oct 3;11(10):32. doi: 10.1167/tvst.11.10.32.
6
Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities.孟德尔随机化：一种预测药物不良反应和药物再利用机会的新方法。
Int J Epidemiol. 2017 Dec 1;46(6):2078-2089. doi: 10.1093/ije/dyx207.
7
TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro.TBK1 是肌萎缩侧索硬化症的优先药物重定位靶点：来自可用药基因组 Mendelian 随机化和体外药理学验证的证据。
BMC Med. 2024 Mar 5;22(1):96. doi: 10.1186/s12916-024-03314-1.
8
Repurposing Antihypertensive and Statin Medications for Spinal Pain: A Mendelian Randomization Study: Erratum.将抗高血压和他汀类药物用于治疗脊柱疼痛的用途拓展：一项孟德尔随机化研究：勘误
Spine (Phila Pa 1976). 2024 Feb 15;49(4):E49. doi: 10.1097/BRS.0000000000004911. Epub 2024 Jan 24.
9
Repurposing Antihypertensive and Statin Medications for Spinal Pain: A Mendelian Randomization Study.抗高血压和他汀类药物在治疗脊柱疼痛中的再利用：一项孟德尔随机化研究。
Spine (Phila Pa 1976). 2023 Nov 15;48(22):1568-1574. doi: 10.1097/BRS.0000000000004790. Epub 2023 Aug 4.
10
A genetically supported drug repurposing pipeline for diabetes treatment using electronic health records.利用电子健康记录进行糖尿病治疗的基因支持药物再利用管道。
EBioMedicine. 2023 Aug;94:104674. doi: 10.1016/j.ebiom.2023.104674. Epub 2023 Jul 1.
引用本文的文献
1
Genomic strategies for drug repurposing.基因组策略在药物再利用中的应用。
J Egypt Natl Canc Inst. 2024 Nov 11;36(1):35. doi: 10.1186/s43046-024-00245-z.
2
Integrating genomics with biomarkers and therapeutic targets to invigorate cardiovascular drug development.将基因组学与生物标志物和治疗靶点相结合，激发心血管药物研发。
Nat Rev Cardiol. 2021 Jun;18(6):435-453. doi: 10.1038/s41569-020-00493-1. Epub 2021 Mar 11.
3
Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases.遗传特征工程使免疫介导性疾病的共享风险因素的特征分析成为可能。
Genome Med. 2020 Nov 25;12(1):106. doi: 10.1186/s13073-020-00797-4.
本文引用的文献
1
Fresh push for 'failed' Alzheimer's drug.对“失败的”阿尔茨海默病药物展开新的推动。
Nature. 2019 Oct 25. doi: 10.1038/d41586-019-03261-5.
2
Repurposing antihypertensive drugs for the prevention of Alzheimer's disease: a Mendelian randomization study.将降压药物重新用于预防阿尔茨海默病：一项孟德尔随机化研究。
Int J Epidemiol. 2020 Aug 1;49(4):1132-1140. doi: 10.1093/ije/dyz155.
3
A genetics-led approach defines the drug target landscape of 30 immune-related traits.遗传学主导的方法定义了 30 种免疫相关特征的药物靶点景观。
Nat Genet. 2019 Jul;51(7):1082-1091. doi: 10.1038/s41588-019-0456-1. Epub 2019 Jun 28.
4
A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice.临床剂量的血管紧张素转化酶（ACE）抑制剂和杂合 ACE 缺失可加重小鼠的阿尔茨海默病病理。
J Biol Chem. 2019 Jun 21;294(25):9760-9770. doi: 10.1074/jbc.RA118.006420. Epub 2019 May 9.
5
Anti-amyloid failures stack up as Alzheimer antibody flops.随着阿尔茨海默病抗体研发失败，抗淀粉样蛋白药物研发失败的情况不断累积。
Nat Rev Drug Discov. 2019 Apr 5. doi: 10.1038/d41573-019-00064-1.
6
Lowering of Amyloid-Beta by β-Secretase Inhibitors - Some Informative Failures.β-分泌酶抑制剂降低β-淀粉样蛋白——一些有参考价值的失败案例
N Engl J Med. 2019 Apr 11;380(15):1476-1478. doi: 10.1056/NEJMe1903193.
7
Phenotypes associated with genes encoding drug targets are predictive of clinical trial side effects.与药物靶点编码基因相关的表型可预测临床试验的副作用。
Nat Commun. 2019 Apr 5;10(1):1579. doi: 10.1038/s41467-019-09407-3.
8
Opportunities and challenges for transcriptome-wide association studies.全转录组关联研究的机遇与挑战。
Nat Genet. 2019 Apr;51(4):592-599. doi: 10.1038/s41588-019-0385-z. Epub 2019 Mar 29.
9
Using genetic drug-target networks to develop new drug hypotheses for major depressive disorder.利用遗传药物靶点网络为重度抑郁症开发新的药物假说。
Transl Psychiatry. 2019 Mar 15;9(1):117. doi: 10.1038/s41398-019-0451-4.
10
Human Genetics and Drug Development.人类遗传学与药物开发
N Engl J Med. 2019 Mar 14;380(11):1076-1079. doi: 10.1056/NEJMe1901565.
Zotero 插件