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Engrafted Donor-Derived Clonal Hematopoiesis after Allogenic Hematopoietic Cell Transplantation is Associated with Chronic Graft-versus-Host Disease Requiring Immunosuppressive Therapy, but no Adverse Impact on Overall Survival or Relapse.异基因造血细胞移植后嵌合供体源性造血与需要免疫抑制治疗的慢性移植物抗宿主病相关，但对总生存或复发无不良影响。
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Clonal hematopoiesis in myeloid malignancies and solid tumors.髓系恶性肿瘤和实体瘤中的克隆性造血
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Donor Cell-Derived Chronic Lymphocytic Leukemia Presenting After Allogenic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia.急性髓系白血病异基因造血干细胞移植后出现供体细胞来源的慢性淋巴细胞白血病
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Pediatric Transplant and Cellular Therapy Consortium RESILIENT Conference on Pediatric Chronic Graft-versus-Host Disease Survivorship after Hematopoietic Cell Transplantation: Part III. Long-Term Impact of Chronic Graft-versus-Host Disease on Endocrinologic, Cardiovascular, and Metabolic Outcomes in Survivors of Pediatric Hematopoietic Cell Transplantation.儿科移植与细胞治疗联盟造血细胞移植后小儿慢性移植物抗宿主病幸存者的RESILIENT会议：第三部分。慢性移植物抗宿主病对小儿造血细胞移植幸存者内分泌、心血管和代谢结局的长期影响。
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Clonal hematopoiesis in the setting of hematopoietic cell transplantation.造血干细胞移植背景下的克隆性造血。
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Clonal hematopoiesis in the donor does not adversely affect long-term outcomes following allogeneic hematopoietic stem cell transplantation: result from a 13-year follow-up.供者克隆性造血不会影响异基因造血干细胞移植后的长期预后：一项 13 年随访研究结果。
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Clonal Hematopoiesis: Role in Hematologic and Non-Hematologic Malignancies.克隆性造血：在血液系统和非血液系统恶性肿瘤中的作用
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本文引用的文献

1
Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation.供者克隆性造血在异基因造血干细胞移植中的作用。
J Clin Oncol. 2019 Feb 10;37(5):375-385. doi: 10.1200/JCO.2018.79.2184. Epub 2018 Nov 7.
2
Diagnosis of Li-Fraumeni Syndrome: Differentiating TP53 germline mutations from clonal hematopoiesis: Results of the observational AGO-TR1 trial.李-佛美尼综合征的诊断：从克隆性造血中区分 TP53 种系突变：观察性 AGO-TR1 试验的结果。
Hum Mutat. 2018 Dec;39(12):2040-2046. doi: 10.1002/humu.23653. Epub 2018 Oct 3.
3
Concise Review: Age-Related Clonal Hematopoiesis: Stem Cells Tempting the Devil.简明综述：与年龄相关的克隆性造血：干细胞诱惑魔鬼。
Stem Cells. 2018 Sep;36(9):1287-1294. doi: 10.1002/stem.2845. Epub 2018 Jun 8.
4
Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells.TET2 缺失可增强 CD19 靶向 T 细胞的治疗效果。
Nature. 2018 Jun;558(7709):307-312. doi: 10.1038/s41586-018-0178-z. Epub 2018 May 30.
5
Lineage restriction analyses in CHIP indicate myeloid bias for and multipotent stem cell origin for .CHIP 中的谱系限制分析表明 偏向于髓系，而 起源于多能干细胞。
Blood. 2018 Jul 19;132(3):277-280. doi: 10.1182/blood-2018-01-829937. Epub 2018 May 15.
6
Misdiagnosis of Li-Fraumeni Syndrome in a Patient With Clonal Hematopoiesis and a Somatic Mutation.患者存在克隆性造血和体细胞突变，导致 Li-Fraumeni 综合征误诊。
J Natl Compr Canc Netw. 2018 May;16(5):461-466. doi: 10.6004/jnccn.2017.7058.
7
Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis.克隆性造血的造血谱系分布和进化动态。
Leukemia. 2018 Sep;32(9):1908-1919. doi: 10.1038/s41375-018-0047-7. Epub 2018 Mar 1.
8
Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes.非血液系统恶性肿瘤患者治疗相关克隆性造血很常见，并与不良临床结局相关。
Cell Stem Cell. 2017 Sep 7;21(3):374-382.e4. doi: 10.1016/j.stem.2017.07.010. Epub 2017 Aug 10.
9
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.克隆性造血与动脉粥样硬化性心血管疾病风险
N Engl J Med. 2017 Jul 13;377(2):111-121. doi: 10.1056/NEJMoa1701719. Epub 2017 Jun 21.
10
Current Use and Trends in Hematopoietic Cell Transplantation in the United States.美国造血细胞移植的当前应用与趋势
Biol Blood Marrow Transplant. 2017 Sep;23(9):1417-1421. doi: 10.1016/j.bbmt.2017.05.035. Epub 2017 Jun 9.

干细胞捐献者不应进行克隆性造血筛查。

Stem cell donors should not be screened for clonal hematopoiesis.

机构信息

Division of Hematological Malignancies, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

出版信息

Blood Adv. 2020 Feb 25;4(4):789-792. doi: 10.1182/bloodadvances.2019000395.

DOI:10.1182/bloodadvances.2019000395
PMID:32097457
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7042999/
Abstract

This article has a companion Point by DeZern and Gondek.

摘要

本文有 DeZern 和 Gondek 的观点与之对应。