Isolated growth hormone deficiency after severe head trauma.

In a 12-yr-old boy growth arrest occurred after severe head trauma. Evaluation of pituitary endocrine function revealed isolated growth hormone (GH) deficiency. Lack of GH response to GH-releasing factor indicated that the responsible lesion was most likely to be localized in the pituitary gland. GH substitution resulted in biochemical (somatomedin increase) and clinical (catch up growth) response.