Zhu Xiaotong, Wu Fu-Lien, Zhu Ting, Liao Fuyuan, Ren Yuanchun, Jan Yih-Kuen
University of Illinois at Urbana-Champaign, Champaign, IL, USA.
Xi'an Technological University, Xi'an, Shaanxi, China.
Int J Low Extrem Wounds. 2021 Jun;20(2):143-149. doi: 10.1177/1534734620905744. Epub 2020 Feb 25.
Weight-bearing exercise such as walking may increase risk of foot ulcers in people with diabetes mellitus (DM) because of plantar ischemia due to repetitive, high plantar pressure. Applications of local vibrations on plantar tissues as a preconditioning intervention before walking may reduce plantar tissue ischemia during walking. The objective of this study was to explore whether preconditioning local vibrations reduce reactive hyperemia after walking. A double-blind, repeated-measures, and crossover design was tested in 10 healthy participants without DM. The protocol included 10-minute baseline, 10-minute local vibrations (100 Hz or sham), 10-minute walking, and 10-minute recovery periods. The order of local vibrations was randomly assigned. Skin blood flow (SBF) was measured over the first metatarsal head during baseline and recovery periods. SBF responses were characterized as peak SBF, total SBF, and recovery time of reactive hyperemia. SBF was expressed as a ratio of recovery to baseline SBF to quantify the changes. Peak SBF in the vibration protocol (6.98 ± 0.87) was significantly lower than the sham control (9.26 ± 1.34, < .01). Total SBF in the vibration protocol ([33.32 ± 7.98] × 10) was significantly lower than the sham control ([48.09 ± 8.9] × 10, < .05). The recovery time in the vibration protocol (166.08 ± 32.71 seconds) was not significantly different from the sham control (223.53 ± 38.85 seconds, = .1). Local vibrations at 100 Hz could reduce walking-induced hyperemic response on the first metatarsal head. Our finding indicates that preconditioning local vibrations could be a potential preventive intervention for people at risk for foot ulcers.
负重运动，如行走，可能会增加糖尿病患者足部溃疡的风险，这是由于重复性的高足底压力导致足底缺血。在行走前对足底组织进行局部振动预处理干预，可能会减少行走过程中足底组织的缺血情况。本研究的目的是探讨预处理局部振动是否能减少行走后的反应性充血。在10名无糖尿病的健康参与者中测试了双盲、重复测量和交叉设计。实验方案包括10分钟的基线期、10分钟的局部振动（100Hz或假刺激）、10分钟的行走和10分钟的恢复期。局部振动的顺序是随机分配的。在基线期和恢复期测量第一跖骨头处的皮肤血流量（SBF）。SBF反应的特征为SBF峰值、总SBF和反应性充血的恢复时间。SBF表示为恢复后与基线SBF的比值，以量化变化。振动方案中的SBF峰值（6.98±0.87）显著低于假刺激对照组（9.26±1.34，P<0.01）。振动方案中的总SBF（[33.32±7.98]×10）显著低于假刺激对照组（[48.09±8.9]×10，P<0.05）。振动方案中的恢复时间（166.08±32.71秒）与假刺激对照组（223.53±38.85秒，P=0.1）无显著差异。100Hz的局部振动可减少行走引起的第一跖骨头充血反应。我们的研究结果表明，预处理局部振动可能是对有足部溃疡风险人群的一种潜在预防干预措施。
