母亲肥胖与胎儿出生时酸中毒的风险。

Maternal obesity and the risk of fetal acidosis at birth.

机构信息

Department of Obstetrics and Gynecology, Hospital Universitario Virgen de las Nieves, Granada, Spain.

Hospital Universitario San Cecilio, Granada, Spain.

出版信息

J Matern Fetal Neonatal Med. 2022 Feb;35(4):765-769. doi: 10.1080/14767058.2020.1731795. Epub 2020 Feb 25.

DOI:10.1080/14767058.2020.1731795

PMID:32098548

Abstract

BACKGROUND

Maternal obesity is a risk factor for multiple obstetrics complications and adverse outcomes. The objective of the study was to investigate the association between obesity (IMC >30) and fetal acidosis at birth.

METHODS AND FINDINGS

This hospital-based cohort study was based on 24,307 live-born infants in which maternal body mass index (BMI) information was available and delivered in the Granada north region during 2007-2018 from data of the Hospital Medical Birth Registry. Multivariate using logistic regression was performed to assess the association between fetal acidosis and BMI, crude, and adjusted odds ratio of fetal acidosis were calculated. < .05 was considered statistically significant. We adjusted by maternal age, parity, hypertension, diabetes, and smoking habits. In the study population of 17,167 term live births, 518 infants (3.02%) had an umbilical cord blood pH < 7.10. The obesity rate in mothers with acidosis at delivery was 12.7%, but morbid obesity rate was 2.51% (adjusted OR 1.82).

CONCLUSION

This study strengthens the evidence that demonstrates that morbid obesity is an independent risk factor for fetal acidosis at birth.

摘要

背景

母体肥胖是多种产科并发症和不良结局的危险因素。本研究的目的是探讨肥胖（BMI＞30）与出生时胎儿酸中毒之间的关系。

方法和发现

这是一项基于医院的队列研究，基于 2007 年至 2018 年期间在格拉纳达北部地区分娩的 24307 名活产婴儿的数据，其中有母亲的体重指数（BMI）信息。采用多变量逻辑回归来评估胎儿酸中毒与 BMI、粗比值比和调整比值比之间的关系。<.05 被认为具有统计学意义。我们调整了母亲的年龄、产次、高血压、糖尿病和吸烟习惯。在 17167 名足月活产儿的研究人群中，有 518 名婴儿（3.02%）脐带血 pH 值＜7.10。酸中毒分娩的母亲肥胖率为 12.7%，但病态肥胖率为 2.51%（调整后的比值比为 1.82）。