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2018 年 5 月至 6 月克罗地亚杜布罗夫尼克-内雷特瓦县麻疹疫情。

Measles outbreak in Dubrovnik-Neretva County, Croatia, May to June 2018.

机构信息

School of Medicine, University of Rijeka, Rijeka, Croatia.

European Programme for Intervention Epidemiology Training (EPIET), European Centre for Disease Prevention and Control, (ECDC), Stockholm, Sweden.

出版信息

Euro Surveill. 2020 Feb;25(7). doi: 10.2807/1560-7917.ES.2020.25.7.1900434.

Abstract

In May 2018, measles was introduced in the Dubrovnik region by an adult who recently travelled to Kosovo*. Control measures and an outbreak investigation were implemented: 15 epidemiologically-linked cases met the outbreak case definition of a visitor/resident of Dubrovnik-Neretva County with laboratory-confirmed measles and symptom onset beginning on May 19. New cases were identified through hospitals and primary care physicians. Throat swabs, urine and/or serum samples were collected from outbreak cases. RT-PCR detection of viral RNA and IgM/IgG was used to confirm infection. The median age of cases was 33 years, with one 8 month-old infant. Vaccination status was unknown for 9 cases, three were unvaccinated, one case had history of one dose and two cases reported receiving two doses of measles-containing vaccine. There were 11 hospitalisations and one person developed pneumonia. Control teams undertook an extensive search of contacts and implemented a range of control measures. Despite the outbreak occurring at the beginning of the summer tourism season, it was contained and did not spread to neighbouring regions. With continuing measles transmission in Europe, even small outbreaks create a burden on the health system in countries which have eliminated measles, and illustrate the importance of maintaining high immunisation coverage.

摘要

2018 年 5 月,一名近期前往科索沃的成年人将麻疹引入杜布罗夫尼克地区。* 实施了控制措施和暴发调查:15 例与暴发相关的病例符合杜布罗夫尼克-内雷特瓦县来访者/居民的暴发病例定义,实验室确诊的麻疹和症状发作始于 5 月 19 日。通过医院和初级保健医生发现新病例。从暴发病例中采集咽拭子、尿液和/或血清样本。使用 RT-PCR 检测病毒 RNA 和 IgM/IgG 以确认感染。病例的中位年龄为 33 岁,有 1 例 8 个月大的婴儿。9 例病例的疫苗接种情况不明,3 例未接种,1 例有 1 剂疫苗接种史,2 例报告接种了含麻疹疫苗 2 剂。有 11 例住院,1 例发展为肺炎。控制小组对接触者进行了广泛搜索,并实施了一系列控制措施。尽管暴发发生在夏季旅游季节开始之际,但得到了控制,并未传播到邻近地区。随着麻疹在欧洲持续传播,即使是小型暴发也会给已消除麻疹的国家的卫生系统带来负担,这说明了保持高免疫覆盖率的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ff0/7043052/4e599b5b66b4/1900434-f1.jpg

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