Tanrıverdi Mahir, Kultursay Nilgun, Tekgul Hasan, Sozmen Eser, Altun Koroglu Ozge, Aktan Gul, Yalaz Mehmet
Division of Neonatology, Department of Pediatrics, Ege Children's Hospital, Ege University Faculty of Medicine, Izmir, Turkey.
Division of Neonatology, Department of Pediatrics, Ege Children's Hospital, Ege University Faculty of Medicine, Izmir, Turkey.
J Clin Neurosci. 2020 Apr;74:168-174. doi: 10.1016/j.jocn.2020.02.013. Epub 2020 Feb 22.
The aim of our study to investigate clinical value of a set of neuropeptides (brain derived neurotrophic factor-BDNF, galanin and neuropeptide Y-NPY) in critically ill neonates. A total of 53 neonates (preterm: 26, term: 27) evaluated with lumbar pucture for etiologic evaluation were consequtively included into the study. Serum and CSF levels of the neuropeptides were measured in the first 48 h of life. All infants were prospectively followed for prognostic outcome (survival and neurodevelopmental) at the first year of life. The study cohort was categorized into four groups with respect to seizure development; preterm neonates with or without seizure and term neonates with or without seizure. Mean CSF levels of NPY (pg/ml) were significantly higher in term neonates with than those without seizures (389.76 vs. 122.66) and galanin (3.31 vs. 1.55) respectively. Term neonates with seizures had significantly higher serum levels of NPY (ng/mL) as compared with neonates without seizures (54.00 vs. 9.10). No significant difference was noted in serum and CSF levels for the set of neuropeptides in neonates with respect to prognostic outcome. Serum NPY and CSF NPY and galanin levels have a potential role for detection of clinical seizures in term neonates.
我们研究的目的是探讨一组神经肽（脑源性神经营养因子-BDNF、甘丙肽和神经肽Y-NPY）在危重新生儿中的临床价值。共有53例因病因评估接受腰椎穿刺的新生儿（早产儿26例，足月儿27例）连续纳入本研究。在出生后的头48小时内测定神经肽的血清和脑脊液水平。所有婴儿在出生后第一年都被前瞻性地跟踪观察预后情况（生存和神经发育）。根据癫痫发作情况，研究队列分为四组：有或无癫痫发作的早产儿和有或无癫痫发作的足月儿。有癫痫发作的足月儿脑脊液中NPY（pg/ml）的平均水平分别显著高于无癫痫发作的足月儿（389.76对122.66）和甘丙肽（3.31对1.55）。与无癫痫发作的新生儿相比，有癫痫发作的足月儿血清中NPY（ng/mL）水平显著更高（54.00对9.10）。就预后情况而言，新生儿组中神经肽的血清和脑脊液水平没有显著差异。血清NPY以及脑脊液NPY和甘丙肽水平在足月儿临床癫痫检测中具有潜在作用。
