Sharifian Afsaneh, Ashtari Sara, Hatami Behzad, Mohebbi Seyed Reza, Naderi Nosratollah
Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Gastroenterol Hepatol Bed Bench. 2019;12(Suppl1):S149-S155.
To investigate routes of transmission, demographic characteristics, and frequency of different phases of chronic hepatitis B (CHB) in 2000 Iranian patients.
Knowledge about the most frequent risk factors of CHB and its different phases is very important for optimal prevention and management policy making.
In this cross-sectional study, 2000 HBsAg positive patients who were referred to Taleghani Hospital from 2011 through 2018 were enrolled. ELISA method was employed to detect serological markers of CHB. Taking into account the HBV DNA and ALT levels and HBeAg status, the patients were classified in four groups, according to AASLD 2017 guideline.
Male and female patients had nearly equal frequencies in our study and 82.5 % of them aged more than 20 years. A great number of our patients (95%) were HBeAg negative and the most frequent risk factors of HBV infection were positive periodontal and family history (40.3% and 24.9%, respectively). The majority of our patients were inactive carriers (63.35%), while s mall number of them were in the immune tolerant group (2.15 %).
Immune tolerance phase group had the minimum number of members in our study and most of them were above 20 years old. This can be due to the mass vaccination of neonates since 1993. Most of CHB patients were in inactive carrier group. Although it is recommended not to treat these patients, performing periodic liver function tests and disease severity assessment is warranted, especially in patients above 40 years old
调查2000例伊朗患者慢性乙型肝炎（CHB）的传播途径、人口统计学特征及不同阶段的发生率。
了解CHB最常见的危险因素及其不同阶段对于制定最佳预防和管理策略非常重要。
在这项横断面研究中，纳入了2011年至2018年转诊至塔莱加尼医院的2000例HBsAg阳性患者。采用ELISA法检测CHB的血清学标志物。根据美国肝病研究学会（AASLD）2017年指南，结合HBV DNA、ALT水平和HBeAg状态，将患者分为四组。
在我们的研究中，男性和女性患者的发生率几乎相等，其中82.5%的患者年龄超过20岁。我们的大量患者（95%）HBeAg阴性，HBV感染最常见的危险因素是牙周病阳性和家族史（分别为40.3%和24.9%）。我们的大多数患者为非活动性携带者（63.35%），而少数患者处于免疫耐受组（2.15%）。
在我们的研究中，免疫耐受期组的成员数量最少，且大多数年龄在20岁以上。这可能是由于自1993年以来新生儿的大规模疫苗接种。大多数CHB患者处于非活动性携带者组。虽然建议不对这些患者进行治疗，但定期进行肝功能检查和疾病严重程度评估是必要的，尤其是对于40岁以上的患者。
