氧化修饰脯氨酸 N 末端的二次修饰用于构建复杂的生物缀合物。
Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates.
机构信息
Department of Chemistry, University of California, Berkeley, California 94720, USA.
Discovery Chemistry, Merck & Co., Inc., Kenilworth, New Jersey 07033, USA.
出版信息
Org Biomol Chem. 2020 Mar 14;18(10):1881-1885. doi: 10.1039/d0ob00211a. Epub 2020 Feb 26.
Abstract
A convenient two-step method is reported for the ligation of alkoxyamine- or hydrazine-bearing cargo to proline N-termini. Using this approach, bifunctional proline N-terminal bioconjugates are constructed and proline N-terminal proteins are immobilized.
摘要
本文报道了一种方便的两步法，用于将烷氧基胺或腙基携带的货物连接到脯氨酸 N 末端。通过这种方法，构建了双功能脯氨酸 N 末端生物缀合物，并固定了脯氨酸 N 末端蛋白质。
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Secondary modification of oxidatively-modified proline N-termini for the construction of complex bioconjugates.氧化修饰脯氨酸 N 末端的二次修饰用于构建复杂的生物缀合物。
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