Thibert R, Akbarieh M, Tawashi R
Faculté de Pharmacie, Université de Montréal, Québec, Canada.
J Pharm Sci. 1988 Aug;77(8):724-6. doi: 10.1002/jps.2600770817.
This report describes the use of fractal analysis in the study of the surface ruggedness of pharmaceutical solids. A comparison of the fractal dimension of granules and excipients prepared by different techniques revealed a possible correlation between the physical behavior of these granules and their surface geometry. The applications of the proposed tool in the study of the surface geometry of pharmaceutical bulk solids are discussed.
本报告描述了分形分析在药物固体表面粗糙度研究中的应用。对通过不同技术制备的颗粒和辅料的分形维数进行比较，揭示了这些颗粒的物理行为与其表面几何形状之间可能存在的相关性。讨论了所提出的工具在药物散装固体表面几何形状研究中的应用。
