配子输卵管内移植（GIFT）和直接腹腔内授精（DIPI）的早期经验。
Early experience with gamete intrafallopian transfer (GIFT) and direct intraperitoneal insemination (DIPI).
作者信息
Dooley M, Lim-Howe D, Savvas M, Studd J W
机构信息
Fertility and Endocrinology Centre, Lister Hospital, London.
出版信息
J R Soc Med. 1988 Nov;81(11):637-9. doi: 10.1177/014107688808101108.
We present our early experience with gamete intrafallopian transfer (GIFT) and direct intraperitoneal insemination (DIPI) combined with intrauterine insemination (IUI), two recently described methods of assisting conception in patients with patent fallopian tubes. Sixty-nine patients (93 cycles) were entered into the study. Thirty-three patients (51 cycles) entered the DIPI/IUI programme and 36 patients (42 cycles) entered the GIFT programme. The mean age, duration and aetiology of infertility were similar in both groups. In the GIFT programme 12 pregnancies occurred, which is a 29% pregnancy rate per cycle and a 33% pregnancy rate per patient. In the DIPI/IUI programme only 3 pregnancies occurred, being a 6% pregnancy rate per cycle and a 9% pregnancy rate per patient. With the live birth rate of in vitro fertilization (IVF) being 12% per embryo transfer, we conclude that GIFT is more successful than either DIPI/IUI or IVF in patients with patent fallopian tubes. Further controlled studies are required to assess the future role of DIPI/IUI in clinical practice.
我们介绍了配子输卵管内移植（GIFT）和直接腹腔内授精（DIPI）联合宫腔内人工授精（IUI）的早期经验，这是最近描述的两种用于输卵管通畅的患者辅助受孕的方法。69例患者（93个周期）进入本研究。33例患者（51个周期）进入DIPI/IUI组，36例患者（42个周期）进入GIFT组。两组患者的平均年龄、不孕持续时间和病因相似。在GIFT组中，有12例妊娠，每个周期的妊娠率为29%，每位患者的妊娠率为33%。在DIPI/IUI组中，仅3例妊娠，每个周期的妊娠率为6%，每位患者的妊娠率为9%。鉴于体外受精（IVF）的每胚胎移植活产率为12%，我们得出结论，对于输卵管通畅的患者，GIFT比DIPI/IUI或IVF更成功。需要进一步的对照研究来评估DIPI/IUI在临床实践中的未来作用。
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