Shanghai Jiaotong University, Shanghai, China.
Huashan Hospital Fudan University, Shanghai, China.
Neurorehabil Neural Repair. 2020 Apr;34(4):321-332. doi: 10.1177/1545968319899919. Epub 2020 Feb 26.
. Reorganization in motor areas have been suggested after motor imagery training (MIT). However, motor imagery involves a large-scale brain network, in which many regions, andnot only the motor areas, potentially constitute the neural substrate for MIT. . This study aimed to identify the targets for MIT in stroke rehabilitation from a voxel-based whole brain analysis of resting-state functional magnetic resonance imaging (fMRI). . Thirty-four chronic stroke patients were recruited and randomly assigned to either an MIT group or a control group. The MIT group received a 4-week treatment of MIT plus conventional rehabilitation therapy (CRT), whereas the control group only received CRT. Before and after intervention, the Fugl-Meyer Assessment Upper Limb subscale (FM-UL) and resting-state fMRI were collected. The fractional amplitude of low-frequency fluctuations (fALFF) in the slow-5 band (0.01-0.027 Hz) was calculated across the whole brain to identify brain areas with distinct changes between 2 groups. These brain areas were then targeted as seeds to perform seed-based functional connectivity (FC) analysis. . In comparison with the control group, the MIT group exhibited more improvements in FM-UL and increased slow-5 fALFF in the ipsilesional inferior parietal lobule (IPL). The change of the slow-5 oscillations in the ipsilesional IPL was positively correlated with the improvement of FM-UL. The MIT group also showed distinct alternations in FCs of the ipsilesional IPL, which were correlated with the improvement of FM-UL. . The rehabilitation efficiency of MIT was associated with increased slow-5 oscillations and altered FC in the ipsilesional IPL. . http://www.chictr.org.cn . . ChiCTR-TRC-08003005.
. 运动想象训练（MIT）后，运动区发生了重组。然而，运动想象涉及到一个大规模的大脑网络，其中许多区域，而不仅仅是运动区，可能构成了 MIT 的神经基础。. 本研究旨在通过静息态功能磁共振成像（fMRI）的基于体素的全脑分析，从脑卒中康复的角度确定 MIT 的靶点。. 招募了 34 名慢性脑卒中患者，并随机分为 MIT 组和对照组。MIT 组接受为期 4 周的 MIT 加常规康复治疗（CRT），而对照组仅接受 CRT。干预前后，采集 Fugl-Meyer 上肢评定量表（FM-UL）和静息态 fMRI。计算整个大脑的慢 5 波段（0.01-0.027 Hz）低频振幅（fALFF），以识别两组之间存在明显变化的脑区。然后将这些脑区作为种子进行基于种子的功能连接（FC）分析。. 与对照组相比，MIT 组在 FM-UL 上的改善更为明显，同侧顶下小叶（IPL）的慢 5 fALFF 增加。同侧 IPL 慢 5 振荡的变化与 FM-UL 的改善呈正相关。MIT 组还表现出同侧 IPL 的 FC 明显改变，与 FM-UL 的改善相关。. MIT 的康复效率与同侧 IPL 中慢 5 振荡的增加和 FC 的改变有关。. http://www.chictr.org.cn.. ChiCTR-TRC-08003005.
