右侧背外侧前额叶皮质的间歇性θ波爆发刺激可改善运动想象能力：一项结合脑电图和功能近红外光谱技术的脑机接口研究

iTBS on RDLPFC improves performance of motor imagery: a brain-computer interface study combining EEG and fNIRS.

作者信息

Chen Jialin, Liu Quan, Chen Gengbin, Cai Guiyuan, Jiang Junbo, Yang Xueru, Tan Chunqiu, Zhang Cailin, Xu Guangqing, Lan Yue

机构信息

Department of Rehabilitation Medicine, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong Province, China.

Postgraduate Research Institute, Guangzhou Sport University, Guangzhou, Guangdong Province, China.

出版信息

J Neuroeng Rehabil. 2025 Jul 31;22(1):172. doi: 10.1186/s12984-025-01688-8.

DOI:10.1186/s12984-025-01688-8

PMID:40745321

Abstract

BACKGROUND

Some individuals using brain-computer interfaces (BCIs) exhibit ineffective control during motor imagery-based BCI (MI-BCI) training. MI-BCI performance correlates with the activation in the frontoparietal attention network, premotor-parietal network, and supplementary motor area (SMA). This study aimed to enhance motor imagery ability and MI-BCI performance by modulating the excitability of the right dorsolateral prefrontal cortex (RDLPFC) through intermittent theta-burst stimulation (iTBS), inducing neuroplastic changes.

METHODS

Fifty-two healthy right-handed participants were randomly assigned to either the iTBS or sham group. They undertook two MI-BCI training sessions, with electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) used to assess acute neuroplasticity changes. The intervention was administered between sessions. Corticospinal excitability and motor imagery vividness were assessed using single-pulse transcranial magnetic stimulation (spTMS) and the Kinesthetic and Visual Imagery Questionnaire-20 (KVIQ-20) before and following the trial.

RESULTS

The iTBS group significantly improved motor state percentage (MSP). Significant µ event-related desynchronization (µ-ERD) was observed at the F4 electrode in the iTBS group. Functional connectivity (FC) analyses revealed decreased connectivity among several electrodes during the post-intervention period. The hemodynamic response function (HRF) indicated significant activation in the right PMC and SMA, with reduced FC among motor areas. No significant differences in MEP, CSP, and KVIQ-20 scores were found between groups.

CONCLUSION

iTBS targeting the RDLPFC may improve MI-BCI training performance and address the "BCI inefficiency" problem. RDLPFC stimulation induced changes in FC of brain regions associated with motor imagery and increased the activation of motor areas, suggesting that the RDLPFC could be a promising target for enhancing motor imagery and optimizing BCI systems.

摘要

背景

一些使用脑机接口（BCI）的个体在基于运动想象的脑机接口（MI-BCI）训练中表现出控制无效的情况。MI-BCI性能与额顶叶注意力网络、运动前区-顶叶网络和辅助运动区（SMA）的激活相关。本研究旨在通过间歇性theta爆发刺激（iTBS）调节右侧背外侧前额叶皮层（RDLPFC）的兴奋性，诱导神经可塑性变化，从而提高运动想象能力和MI-BCI性能。

方法

52名健康右利手参与者被随机分配到iTBS组或假刺激组。他们进行了两次MI-BCI训练，使用脑电图（EEG）和功能近红外光谱（fNIRS）评估急性神经可塑性变化。干预在两次训练之间进行。在试验前后，使用单脉冲经颅磁刺激（spTMS）和动觉与视觉想象问卷-20（KVIQ-20）评估皮质脊髓兴奋性和运动想象生动性。

结果

iTBS组的运动状态百分比（MSP）显著提高。在iTBS组的F4电极处观察到显著的μ事件相关去同步化（μ-ERD）。功能连接性（FC）分析显示，干预后几个电极之间的连接性降低。血流动力学响应函数（HRF）表明右侧运动前区和SMA有显著激活，运动区域之间的FC降低。两组之间在运动诱发电位（MEP）、皮质静息期（CSP）和KVIQ-20评分方面没有显著差异。