出生后24小时内低血压的治疗与极低出生体重儿听力损失风险
Treatment for hypotension in the first 24 postnatal hours and the risk of hearing loss among extremely low birth weight infants.
作者信息
Gogcu Semsa, Washburn Lisa, O'Shea T Michael
机构信息
Department of Pediatrics, Neonatal-Perinatal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
出版信息
J Perinatol. 2020 May;40(5):774-780. doi: 10.1038/s41372-020-0628-y. Epub 2020 Feb 26.
OBJECTIVE
To evaluate whether treated hypotension in the first 24 postnatal hours is associated with hearing loss in extremely low birth weight (ELBW) infants.
STUDY DESIGN
In a cohort of 735 ELBW infants, we identified 25 with sensorineural hearing loss (SNHL) at 12-24 months adjusted age. For each case, we selected three controls with normal hearing. Logistic regression models were used to adjust for confounding variables.
RESULTS
Sixty percent of cases and 25% of controls were treated for hypotension. After adjusting for confounding variables (gestational age, antenatal glucocorticoids, 5 min Apgar < 6, insertion of an umbilical catheter, treatment with high frequency ventilation, and major cranial ultrasound abnormality), treated hypotension was associated with an increased risk of SNHL (adjusted odds ratio: 3.6; 95% confidence interval: 1.3-9.7).
CONCLUSIONS
Treated hypotension in ELBW infants in the first 24 h of life is associated with an increased risk of SNHL.
目的
评估出生后最初24小时内治疗的低血压是否与极低出生体重（ELBW）婴儿的听力损失有关。
研究设计
在一组735名ELBW婴儿中，我们确定了25名在矫正年龄12至24个月时患有感音神经性听力损失（SNHL）的婴儿。对于每例病例，我们选择了三名听力正常的对照。使用逻辑回归模型对混杂变量进行校正。
结果
60%的病例和25%的对照接受了低血压治疗。在校正混杂变量（胎龄、产前糖皮质激素、5分钟阿氏评分<6、脐静脉导管插入、高频通气治疗和主要颅脑超声异常）后，治疗的低血压与SNHL风险增加相关（校正比值比：3.6；95%置信区间：1.3 - 9.7）。
结论
ELBW婴儿出生后最初24小时内治疗的低血压与SNHL风险增加有关。
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