Center for Inflammation Research, VIB, Ghent, Belgium.
Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
Eur J Immunol. 2020 Apr;50(4):490-493. doi: 10.1002/eji.202048582. Epub 2020 Mar 13.
With the legendary saying of Leonardo da Vinci in the title, we suggest that Glucocorticoid Induced Leucine Zipper (GILZ) may have more promising effects against polymicrobial sepsis, than glucocorticoids (GC). Indeed, the use of GCs in sepsis remains a matter of debate. The rationale for their use in sepsis is to modulate the exaggerated inflammatory response while maintaining innate immunity. However, GC resistance and side-effects limit their therapeutic value in sepsis. Hence, there is a growing interest in understanding the mechanisms by which GCs modulate immune responses upon infection. In this issue of the European Journal of Immunology, Ellouze et al. provide data demonstrating that deregulated expression of GILZ, a GC-induced protein, in monocytes/macrophages (M/M) recovered from septic shock patients may contribute to the pathogenesis. Furthermore, the authors demonstrate that GILZ overexpression in M/M improves outcome in septic animals by limiting systemic inflammation while increasing bacterial clearance. Overall, these data provide evidence that GCs may modulate immune responses via GILZ and that GILZ is a valuable alternative for GC therapy in sepsis.
标题引用了莱昂纳多·达·芬奇的名言，我们提出，糖皮质激素诱导亮氨酸拉链（GILZ）可能比糖皮质激素（GC）对多微生物性败血症有更有前途的疗效。事实上，GC 在败血症中的应用仍然存在争议。使用 GC 的理由是调节过度的炎症反应，同时保持先天免疫。然而，GC 抵抗和副作用限制了它们在败血症中的治疗价值。因此，人们越来越感兴趣地了解 GC 在感染时调节免疫反应的机制。在本期《欧洲免疫学杂志》上，Ellouze 等人提供的数据表明，从败血症休克患者中恢复的单核细胞/巨噬细胞（M/M）中 GILZ（一种 GC 诱导的蛋白）表达失调可能有助于发病机制。此外，作者证明，M/M 中的 GILZ 过表达通过限制全身炎症而增加细菌清除率，从而改善败血症动物的预后。总的来说，这些数据提供了证据表明，GC 可能通过 GILZ 来调节免疫反应，而 GILZ 是败血症中 GC 治疗的一种有价值的替代方法。
