Kimura M, Muroi M, Kimura I, Sakai S, Kitagawa I
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan.
Jpn J Pharmacol. 1988 Oct;48(2):290-3. doi: 10.1254/jjp.48.290.
The neuromuscular blocking actions of several constituents extracted from Japanese-sino medicine, aconite, were compared in mouse phrenic nerve-diaphragm muscle preparations. Hypaconitine (HAT) was more potent than aconitine (ATN), mesaconitine (MAT) and deoxyaconitine. Lipohypaconitine, coryneine and lipodeoxyaconitine were less effective. Lipoaconitine, benzoylmesaconine, higenamine, kobusine and chasmanine were not effective. The blockades by HAT, ATN and MAT were not recovered by neostigmine. The mechanisms of blockade were similar to that of aconite crude extract. These results suggest that aconite action is dependent on HAT, a main constituent.
在小鼠膈神经-膈肌标本中比较了从日本汉方药附子中提取的几种成分的神经肌肉阻滞作用。次乌头碱（HAT）比乌头碱（ATN）、中乌头碱（MAT）和去氧乌头碱的作用更强。脂乌头碱、紫堇碱和脂去氧乌头碱的效果较差。脂乌头碱、苯甲酰中乌头碱、去甲乌药碱、紫堇灵和查斯曼宁无效。新斯的明不能逆转HAT、ATN和MAT引起的阻滞。其阻滞机制与附子粗提取物相似。这些结果表明附子的作用取决于其主要成分HAT。
