卡拉奇一家三级医疗医院中儿童的疟疾性肝病

Malarial Hepatopathy in Children Visiting a Tertiary Healthcare Hospital in Karachi.

作者信息

Maheshwari Nathumal, Shaikh Mehmood, Chand Rewa, Maheshwari Hemandas, Yasir Mehrunnisa

机构信息

Pediatrics, Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, PAK.

Neonatal Intensive Care Unit, Jinnah Sindh Medical University, Karachi, PAK.

出版信息

Cureus. 2020 Jan 18;12(1):e6696. doi: 10.7759/cureus.6696.

DOI:10.7759/cureus.6696

PMID:32104632

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7026864/

Abstract

Objective To determine the frequency of malarial hepatopathy in children that are visiting Lyari General Hospital in Karachi, Pakistan. Study design Cross sectional descriptive study. Material and methods Patients with age between two months and 15 years, who had positive blood film for Plasmodium falciparum or P. vivax, were included in the study. All patients were monitored for malarial hepatopathy. Result A total of 241 cases were included in the study. Mean age at admission was 4.1 ± 1.3 years and male to female ratio was 1.2:1. There were 133 (55.2%) cases of P. vivax, while 108 (44.8%) were of P. falciparum. Malarial hepatopathy was observed in 37 patients (15.4%). Malaria hepatopathy was present in 24.1% and 8.3% children having P. falciparum and P. vivax, respectively. Malaria hepatopathy was present in 24%, 18% and 6% in age groups two months to five years, >5 years to 10 years and >10 years, respectively. Conclusion Malarial hepatopathy was observed in about one-sixth of study population and it was more common between two months and five years age group.

摘要

目的确定在巴基斯坦卡拉奇利亚里综合医院就诊的儿童疟疾性肝病的发生率。研究设计横断面描述性研究。材料与方法年龄在两个月至15岁之间、疟原虫血涂片检测为恶性疟原虫或间日疟原虫阳性的患者纳入本研究。所有患者均接受疟疾性肝病监测。结果本研究共纳入241例病例。入院时的平均年龄为4.1±1.3岁，男女比例为1.2:1。间日疟原虫病例有133例（55.2%），而恶性疟原虫病例有108例（44.8%）。37例患者（15.4%）观察到疟疾性肝病。患恶性疟原虫和间日疟原虫的儿童中，疟疾性肝病的发生率分别为24.1%和8.3%。在两个月至五岁、>5岁至10岁和>10岁年龄组中，疟疾性肝病的发生率分别为24%、18%和6%。结论在约六分之一的研究人群中观察到疟疾性肝病，且在两个月至五岁年龄组中更为常见。