对映选择性酮与外消旋仲醇通过氢借催化的烷基化反应。
Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis.
机构信息
Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
出版信息
Chem Commun (Camb). 2020 Mar 24;56(24):3543-3546. doi: 10.1039/d0cc00767f.
PMID:32104853
Abstract
An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched β-substituted ketone products were readily cleaved to a wide range of functional groups via retro-Friedel-Crafts acylation.
摘要
本文描述了一种对映选择性方法，用于手性仲醇对邻位二取代芳基酮的烷基化反应。该过程由商业可得的铱催化剂介导，并通过氢借催化进行。高对映选择性的β-取代酮产物可通过反 Friedel-Crafts 酰基化轻易地转化为广泛的官能团。
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