Ha Mihyang, Kim Jayoung, Park Su Min, Hong Chae Mi, Han Myoung-Eun, Song Parkyong, Kang Chi-Dug, Lee Dongjun, Kim Yun Hak, Hur Jin, Oh Sae-Ock
Department of Anatomy, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Department of Convergence Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea.
Genet Test Mol Biomarkers. 2020 Mar;24(3):145-149. doi: 10.1089/gtmb.2019.0185. Epub 2020 Feb 27.
The zinc finger homeobox 4 (ZFHX4) protein is a crucial molecular regulator of tumor-initiating stem cell-like functions. This study aimed to determine the role of ZFHX4 in the progression of ovarian serous cystadenocarcinoma (OSC). Differential gene expression among low-stage (stages I and II), high-stage (stages III and IV), low-grade (grades I and II), and high-grade (grades III and IV) OSC patients was identified using four independent cohorts from the Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus (GEO). We compared expression as a prognostic factor using Kaplan-Meier survival curves, multivariate analysis, the time-dependent area under the curve (AUC) of Uno's C-index, and the AUC of the receiver operating characteristics at 4 years post diagnosis. gene expression in high-stage tumors is significantly higher than in low-stage tumors (TCGA, = 0.007; GSE9891, = 0.001). A Kaplan-Meier analysis revealed that elevated expression of was associated with a poor prognosis in OSC patients for all cohorts, regardless of stage and grade (TCGA, = 1e-04; GSE9891, = 0.0044; GSE13876, = 0.00078; GSE26712, = 0.039). Analysis of C-indices and the area under the receiver operating characteristic curve further supported this result (C-index: TCGA, 0.599; GSE9891, 0.642; GSE13876, 0.585; GSE26712, 0.597). Moreover, univariate and multivariate Cox hazards analyses confirmed the prognostic significance of levels. Collectively, these findings suggest that ZFHX4 is a prognostic factor for OSC.
锌指同源盒4（ZFHX4）蛋白是肿瘤起始干细胞样功能的关键分子调节因子。本研究旨在确定ZFHX4在卵巢浆液性囊腺癌（OSC）进展中的作用。使用来自癌症基因组图谱（TCGA）和基因表达综合数据库（GEO）的四个独立队列，确定了低分期（I期和II期）、高分期（III期和IV期）、低级别（I级和II级）和高级别（III级和IV级）OSC患者之间的差异基因表达。我们使用Kaplan-Meier生存曲线、多变量分析、Uno's C指数的时间依赖性曲线下面积（AUC）以及诊断后4年的受试者工作特征曲线的AUC，将基因表达作为一个预后因素进行比较。高分期肿瘤中的基因表达显著高于低分期肿瘤（TCGA，P = 0.007；GSE9891，P = 0.001）。Kaplan-Meier分析显示，无论分期和级别如何，所有队列中OSC患者中该基因表达升高均与预后不良相关（TCGA，P = 1e - 04；GSE9891，P = 0.0044；GSE13876，P = 0.00078；GSE26712，P = 0.039）。C指数和受试者工作特征曲线下面积分析进一步支持了这一结果（C指数：TCGA，0.599；GSE9891，0.642；GSE13876，0.585；GSE26712，0.597）。此外，单变量和多变量Cox风险分析证实了该基因水平的预后意义。总的来说，这些发现表明ZFHX4是OSC的一个预后因素。
