转移 RNA：生物系统起源中的分子造物主。

Transfer RNA: The molecular demiurge in the origin of biological systems.

机构信息

Laboratório de Genética Evolutiva Paulo Leminsk, Departamento de Biologia Molecular, Universidade Federal da Paraíba, João Pessoa, Brazil.

Theoretical Biology Group, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México CDMX, C.P. 04510, Mexico.

出版信息

Prog Biophys Mol Biol. 2020 Jul;153:28-34. doi: 10.1016/j.pbiomolbio.2020.02.006. Epub 2020 Feb 24.

DOI:10.1016/j.pbiomolbio.2020.02.006

PMID:32105652

Abstract

Herein, we review recent works on the role that the tRNA molecule played in the early origins of biological systems. tRNAs gave origin to the first genes (mRNA), the peptidyl transferase center (PTC), the 16S ribosomal molecule, proto-tRNAs were at the core of a proto-translation system, and the anticodon and operational codes appeared in tRNAs molecules. Metabolic pathways emerged from evolutionary pressures of the decoding systems. The transitions from the RNA world to the ribonucleoprotein world to modern biological systems were driven by two kinds of tRNAs transitions, to wit, tRNAs leading to both mRNA and rRNA.

摘要

本文回顾了近年来关于 tRNA 分子在生物系统早期起源中所扮演的角色的研究工作。tRNA 产生了第一批基因（mRNA）、肽基转移酶中心（PTC）、16S 核糖体分子，原 tRNA 是原翻译系统的核心，反密码子和操作码出现在 tRNA 分子中。代谢途径是由解码系统的进化压力产生的。从 RNA 世界到核糖核蛋白世界再到现代生物系统的转变，是由两种 tRNA 的转变驱动的，即既导致 mRNA 又导致 rRNA 的 tRNA。