Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610065, China.
Department of Food Science and Technology, College of Biomass and Engineering and Healthy Food Evaluation Research Center, Sichuan University, Chengdu, 610065, China.
Epilepsy Res. 2020 Mar;161:106299. doi: 10.1016/j.eplepsyres.2020.106299. Epub 2020 Feb 19.
Mesial temporal lobe epilepsy (mTLE), a very common chronic neurological disorder, is frequently accompanied by neurodegeneration in the hippocampus, resulting in hippocampal sclerosis (HS); HS is the most common morphological correlate of drug resistance in mTLE patients. Incomplete knowledge of pathological changes in mTLE with HS complicates its therapy. Growing evidence indicates a role of lipid signaling pathways in epileptogenesis; thus, lipid signals emerge as potential biomarkers for the onset and evolving course of this epileptic disorder, and are potential therapeutic agents and targets. Therefore, in this study, we recruited 23 patients with medically intractable mTLE-HS and 24 non-mTLE-HS controls. We applied lipidomic analysis to identify the lipidomic profiles in the hippocampal samples of both groups. The lipidomic profiles of the hippocampus were distinctive between mTLE-HS patients and controls. We also observed that the abundance of total triglycerides showed a striking reduction in the hippocampus of mTLE-HS patients. We identified that 33 lipids were significantly differentially expressed in the hippocampus of mTLE-HS patients compared with those in the hippocampus of the controls; this might contribute to target some molecular mechanisms involved in epileptogenesis. The present study therefore reports that lipidomic changes in mTLE-HS patients may contribute to the molecular architecture of an epileptic brain.
内侧颞叶癫痫（mTLE）是一种非常常见的慢性神经系统疾病，常伴有海马神经元变性，导致海马硬化（HS）；HS 是 mTLE 患者药物抵抗的最常见形态学相关因素。对伴有 HS 的 mTLE 的病理变化认识不足，使其治疗复杂化。越来越多的证据表明脂质信号通路在癫痫发生中的作用；因此，脂质信号可能成为这种癫痫疾病发作和进展的潜在生物标志物，也是潜在的治疗剂和靶点。因此，在这项研究中，我们招募了 23 名药物难治性 mTLE-HS 患者和 24 名非 mTLE-HS 对照组。我们应用脂质组学分析来鉴定两组海马样本中的脂质组学特征。mTLE-HS 患者和对照组的海马脂质组学特征明显不同。我们还观察到 mTLE-HS 患者海马组织中总甘油三酯的含量明显减少。我们发现，与对照组相比，mTLE-HS 患者海马中有 33 种脂质显著差异表达；这可能有助于针对一些参与癫痫发生的分子机制。因此，本研究报告称，mTLE-HS 患者的脂质组学变化可能有助于癫痫大脑的分子结构。
