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晚期痴呆患者群体中抗菌药物耐药基因的流行情况与特定致病共生菌有关。

Antimicrobial Resistance Gene Prevalence in a Population of Patients with Advanced Dementia Is Related to Specific Pathobionts.

作者信息

Rowan-Nash Aislinn D, Araos Rafael, D'Agata Erika M C, Belenky Peter

机构信息

Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA.

Instituto de Ciencias e Innovación en Medicina (ICIM), Facultad de Medicina Clinica Alemana Universidad del Desarrollo, Santiago, Chile; Millenium Nucleus for Collaborative Research on Bacterial Resistance (MICROB-R), Santiago, Chile; Advanced Center for Chronic Diseases (ACCDiS), Facultad de Medicina Clinica Alemana Universidad del Desarrollo, Santiago, Chile.

出版信息

iScience. 2020 Mar 27;23(3):100905. doi: 10.1016/j.isci.2020.100905. Epub 2020 Feb 13.

DOI:10.1016/j.isci.2020.100905
PMID:32106056
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7044522/
Abstract

Long-term care facilities are significant reservoirs of antimicrobial-resistant organisms, and patients with advanced dementia are particularly vulnerable to multidrug-resistant organism (MDRO) acquisition and antimicrobial overuse. In this study, we longitudinally examined a group of patients with advanced dementia using metagenomic sequencing. We found significant inter- and intra-subject heterogeneity in microbiota composition, suggesting temporal instability. We also observed a link between the antimicrobial resistance gene density in a sample and the relative abundances of several pathobionts, particularly Escherichia coli, Proteus mirabilis, and Enterococcus faecalis, and used this relationship to predict resistance gene density in samples from additional subjects. Furthermore, we used metagenomic assembly to demonstrate that these pathobionts had higher resistance gene content than many gut commensals. Given the frequency and abundances at which these pathobionts were found in this population and the underlying vulnerability to MDRO of patients with advanced dementia, attention to microbial blooms of these species may be warranted.

摘要

长期护理机构是耐抗菌生物体的重要储存库，晚期痴呆患者尤其容易感染多重耐药生物体（MDRO）并过度使用抗菌药物。在本研究中，我们使用宏基因组测序对一组晚期痴呆患者进行了纵向研究。我们发现微生物群组成在个体间和个体内存在显著异质性，表明存在时间不稳定性。我们还观察到样本中的抗菌抗性基因密度与几种致病共生菌的相对丰度之间存在联系，特别是大肠杆菌、奇异变形杆菌和粪肠球菌，并利用这种关系预测其他受试者样本中的抗性基因密度。此外，我们使用宏基因组组装来证明这些致病共生菌的抗性基因含量高于许多肠道共生菌。鉴于在该人群中发现这些致病共生菌的频率和丰度，以及晚期痴呆患者对MDRO的潜在易感性，可能有必要关注这些物种的微生物大量繁殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/96e3d28c4c82/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/257d5fde4396/fx1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/3c34aa219dff/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/6bd02699d87d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/eb89991daf84/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/65928abce6af/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/96e3d28c4c82/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/257d5fde4396/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/358207e8e0eb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/3c34aa219dff/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/6bd02699d87d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/eb89991daf84/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/65928abce6af/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ccb/7044522/96e3d28c4c82/gr6.jpg

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