Department of Child and Adolescent Psychiatry, Düzce University Faculty of Medicine, Düzce, Turkey.
Clin Neuropharmacol. 2020 Mar/Apr;43(2):46-47. doi: 10.1097/WNF.0000000000000379.
"Skin picking disorder," also known as "dermatillomania" or "psychogenic excoriation," is classified in the "Obsessive Compulsive and Related Disorders" category in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition and characterized by repetitive skin picking behaviors resulting in skin lesions. Atomoxetine (ATX) is a selective norepinephrine (noradrenaline) reuptake inhibitor commonly used in the management of attention-deficit/hyperactivity disorder. Atomoxetine is considered to increase levels of noradrenaline and dopamine by inhibiting norepinephrine transporters. In this case report, we present an 8-year-old male attention-deficit/hyperactivity disorder patient with skin picking behavior due to ATX treatment. We discussed possible explanations of skin picking behavior with ATX in the light of the current literature. To our knowledge, this is the first report of skin picking due to ATX in literature, and further studies are needed to investigate the frequency and mechanisms of skin picking with ATX.
“皮肤搔抓障碍”，又称“皮肤搔抓癖”或“精神性搔抓”，在《精神障碍诊断与统计手册》第五版中被归类为“强迫症及相关障碍”类别，其特征是反复出现的皮肤搔抓行为导致皮肤损伤。托莫西汀（ATX）是一种常用于治疗注意缺陷/多动障碍的选择性去甲肾上腺素（去甲肾上腺素）再摄取抑制剂。托莫西汀被认为通过抑制去甲肾上腺素转运体来增加去甲肾上腺素和多巴胺的水平。在本病例报告中，我们报告了一名 8 岁男性注意缺陷/多动障碍患者，因 ATX 治疗出现皮肤搔抓行为。我们根据现有文献讨论了 ATX 引起皮肤搔抓行为的可能解释。据我们所知，这是文献中首例因 ATX 引起的皮肤搔抓报告，需要进一步研究以调查 ATX 引起皮肤搔抓的频率和机制。
