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转谷氨酰胺酶 3 可减轻咪喹莫特诱导的小鼠皮肤银屑病的严重程度。

Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin.

机构信息

Department of Experimental Medicine, TOR, University of Rome "Tor Vergata", 00133 Rome, Italy.

Dermatology Unit, Department of Biotechnological and Applied Clinical Science, University of L'Aquila, IT-67100 L'Aquila, Italy.

出版信息

Int J Mol Sci. 2020 Feb 25;21(5):1566. doi: 10.3390/ijms21051566.

DOI:10.3390/ijms21051566
PMID:32106600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7084269/
Abstract

Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evaluated the severity of psoriasis markers in the skin of imiquimod-treated TG3 null and TG2 null mice. Our results showed that compromised TG3KO mouse skin was more responsive than WT or TG2KO mouse skin to the action of the pro-inflammatory drug imiquimod.

摘要

已经在表皮角质形成细胞中检测到四种转谷氨酰胺酶 (TG) 同工型：TG1、TG2、TG3 和 TG5。除了 TG1 和 TG3 之外，它们对角质形成细胞发育和结构的贡献仍未确定。在本文中，我们专注于 TG2 和 TG3 在咪喹莫特诱导的小鼠皮肤银屑病中的作用。我们评估了咪喹莫特处理的 TG3 敲除和 TG2 敲除小鼠皮肤中银屑病标志物的严重程度。我们的结果表明，与 WT 或 TG2KO 小鼠皮肤相比，功能丧失的 TG3KO 小鼠皮肤对促炎药物咪喹莫特的作用更为敏感。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c93/7084269/4f5bbbec0b1b/ijms-21-01566-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c93/7084269/13d2c9b373b6/ijms-21-01566-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c93/7084269/285807766024/ijms-21-01566-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c93/7084269/504c39ac41c1/ijms-21-01566-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c93/7084269/4f5bbbec0b1b/ijms-21-01566-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c93/7084269/13d2c9b373b6/ijms-21-01566-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c93/7084269/285807766024/ijms-21-01566-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c93/7084269/504c39ac41c1/ijms-21-01566-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c93/7084269/4f5bbbec0b1b/ijms-21-01566-g004.jpg

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本文引用的文献

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