Hodges J K, Tarara R, Wangula C
MRC/ARC Comparative Physiology Research Group, The Institute of Zoology, The Zoological Society of London, Regent's Park, London, United Kingdom.
Institute of Primate Research, National Museums of Kenya, Nairobi, Kenya, Africa.
Am J Primatol. 1984;7(4):357-366. doi: 10.1002/ajp.1350070404.
Ovarian and placental steroid secretion was examined at intervals during early and mid-pregnancy in the olive baboon, Papio anubis. Progesterone, androstenedione, testosterone, estrone, and estradiol-17β were measured after celite chromatography in samples from peripheral circulation and from utero-ovarian veins draining ovaries with and without corpora lutea at the following stages of pregnancy: days 8-9 (unconfirmed pregnant), 10-19, 34-40, 60-66, and 104-106 after ovulation. The pattern of hormone levels in peripheral and utero-ovarian vein samples indicated the following: 1) The corpus luteum was the principal source of progesterone until at least day 19. Placental secretion was well advanced by days 34-40 and provided the major contribution to circulating progesterone levels by day 60.2) There was a significant elevation in peripheral concentrations of androstenedione and testosterone on days 10-19 and 34-40 of pregnancy; androgen levels in peripheral and utero-ovarian vein samples declined to baseline values by day 60. 3) Estrogens were secreted by the corpus luteum on days 10-19 but not on days 34-40. Placental secretion of estradiol-17β increased markedly after days 60-66, whereas little, if any, placental secretion of estrone was apparent at this time. These results provide circumstantial evidence that progesterone secretion by the corpus luteum of early pregnancy extends beyond the time when estrogen secretion has declined and that the timing of the luteo-placental shift in the baboon is intermediate between that in rhesus monkeys and that in marmosets and humans. Increased secretion of androgens during the first 6 weeks of gestation may be useful in early pregnancy diagnosis in the baboon, although the physiological significance of this event is not clear.
在妊娠早期和中期，对东非狒狒（Papio anubis）的卵巢和胎盘类固醇分泌情况进行了定期检查。在排卵后的以下妊娠阶段：第8 - 9天（未确认怀孕）、第10 - 19天、第34 - 40天、第60 - 66天和第104 - 106天，对来自外周循环以及来自子宫 - 卵巢静脉（引流有和没有黄体的卵巢）的样本进行硅藻土色谱分析后，测量孕酮、雄烯二酮、睾酮、雌酮和雌二醇 - 17β。外周和子宫 - 卵巢静脉样本中的激素水平模式表明如下情况：1）黄体是孕酮的主要来源，至少持续到第19天。胎盘分泌在第34 - 40天已充分发展，并在第60天对循环孕酮水平起主要作用。2）在妊娠第10 - 19天和第34 - 40天，外周雄烯二酮和睾酮浓度显著升高；到第60天，外周和子宫 - 卵巢静脉样本中的雄激素水平降至基线值。3）黄体在第10 - 19天分泌雌激素，但在第34 - 40天不分泌。第60 - 66天后，胎盘雌二醇 - 17β的分泌显著增加，而此时胎盘雌酮的分泌即使有也很少。这些结果提供了间接证据，表明妊娠早期黄体分泌孕酮的时间超过了雌激素分泌下降的时间，并且狒狒中黄体 - 胎盘转换的时间介于恒河猴与狨猴和人类之间。妊娠前6周雄激素分泌增加可能有助于东非狒狒的早期妊娠诊断，尽管这一事件的生理意义尚不清楚。
