Medical Centre, University of Rajshahi, Rajshahi, Bangladesh.
Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, Bangladesh.
PLoS One. 2020 Feb 27;15(2):e0229539. doi: 10.1371/journal.pone.0229539. eCollection 2020.
Bipolar disorder (BPD) is a major mental disorder which not only affects the personal and social functioning of an individual, but also inflicts a huge economic burden on the family. Yet, the study of BPD in Bangladesh is rare and poorly documented. Responding to the dire need, we conducted a new study to determine the prevalence of, and detect the associated factors of, BPD among married women in Rajshahi City, Bangladesh.
We conducted a cross-sectional study, selecting households in Rajshahi City using a multi-stage random sampling design. The data consisted of 279 married women, who were screened for BPD using the bipolar spectrum diagnostic scale (BSDS). Frequency distribution, chi-square test and binary logistic regression model were used respectively to determine the prevalence, identify the associated factors and quantify their effects on BPD.
The prevalence of BPD among married women in Rajshahi City was 2.5%, with an additional 7.2% classified as probable BPD. A binary logistic regression analysis established the following six main factors of BPD: (1) comorbid mental disorder [AOR = 8.232, 95% CI = (1.397, 50.000), p<0.05]; (2) poor relationship with husband [AOR = 11.775, 95% CI = (2.070, 66.667), p<0.01]; (3) poverty [AOR = 1.600, 95% CI = (2.086, 122.709), p<0.01]; (4) high educational level [AOR = 0.177, 95% CI = (0.037, 0.843), p<0.05]; (5) lack of immediate treatment if sick [AOR = 2.941, 95% CI = (1.259, 6.871), p<0.05]; and (6) death of beloved one/s [AOR = 2.768, 95% CI = (1.130, 6.777), p<0.05].
Our survey involved self-reporting, which is typically affected by differing levels of understanding and bias. Also, a cross-sectional, observational study cannot establish an actual cause-and-effect relationship. Some other potentially important factors such as environment, lifestyle, familial customs, effects of drugs, treatment options and outcomes, etc. were not studied. Also, save mental disorder, all other comorbidities remained undocumented.
This study laid down the foundation for conducting further research on identifying different factors affecting BPD, and for studying other issues related to BPD among married women in Bangladesh. Among such factors are familial environment and culture, comorbidities, treatment options, treatment outcomes, biochemical feature, environmental factors, etc. This study also recommends that, while treating BPD patients, health professionals should focus on comorbidities and family matters.
双相情感障碍(BPD)是一种主要的精神障碍,不仅影响个人的个人和社会功能,而且给家庭带来巨大的经济负担。然而,孟加拉国对 BPD 的研究很少且记录不佳。为了应对这一迫切需求,我们进行了一项新的研究,以确定孟加拉国拉杰沙希市已婚妇女中 BPD 的患病率,并发现相关因素。
我们进行了一项横断面研究,使用多阶段随机抽样设计选择拉杰沙希市的家庭。数据包括 279 名已婚妇女,她们使用双相谱诊断量表(BSDS)筛查 BPD。分别使用频率分布、卡方检验和二元逻辑回归模型来确定患病率、确定相关因素并量化它们对 BPD 的影响。
拉杰沙希市已婚妇女中 BPD 的患病率为 2.5%,另有 7.2%被归类为可能的 BPD。二元逻辑回归分析确定了以下六个 BPD 的主要因素:(1)合并精神障碍[比值比(AOR)= 8.232,95%置信区间(CI)=(1.397,50.000),p<0.05];(2)与丈夫关系不好[AOR = 11.775,95%CI =(2.070,66.667),p<0.01];(3)贫困[AOR = 1.600,95%CI =(2.086,122.709),p<0.01];(4)高教育水平[AOR = 0.177,95%CI =(0.037,0.843),p<0.05];(5)生病时缺乏即时治疗[AOR = 2.941,95%CI =(1.259,6.871),p<0.05];和(6)心爱之人的死亡[AOR = 2.768,95%CI =(1.130,6.777),p<0.05]。
我们的调查涉及自我报告,这通常受到不同理解和偏见程度的影响。此外,横断面观察性研究不能建立实际的因果关系。还有一些其他可能重要的因素,如环境、生活方式、家庭习俗、药物影响、治疗选择和结果等,没有研究。此外,除了精神障碍外,所有其他合并症都没有记录。
本研究为进一步研究确定影响 BPD 的不同因素以及研究孟加拉国已婚妇女中与 BPD 相关的其他问题奠定了基础。这些因素包括家庭环境和文化、合并症、治疗选择、治疗结果、生化特征、环境因素等。本研究还建议,在治疗 BPD 患者时,卫生专业人员应关注合并症和家庭问题。