三氯化铁促进的α,β-炔基对甲苯磺酰腙与二硒醚的环化反应:4-(芳基硒基)-1H-吡唑的合成。
Iron(iii) chloride-promoted cyclization of α,β-alkynic tosylhydrazones with diselenides: synthesis of 4-(arylselanyl)-1H-pyrazoles.
机构信息
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Centre of Suzhou Nano Science and Technology, Soochow University, China.
出版信息
Org Biomol Chem. 2020 Mar 14;18(10):1987-1993. doi: 10.1039/d0ob00048e. Epub 2020 Feb 28.
A highly efficient iron(iii) chloride-promoted cyclization between α,β-alkynic tosylhydrazones and diselenides to form a 4-(arylselanyl)-1H-pyrazole skeleton is studied. This reaction forms C-N and C-Se bonds in one step by utilizing inexpensive iron(iii) chloride instead of expensive transition metal additives. This strategy features easily synthesized substrates, mild reaction conditions and high tolerance to functional groups.
研究了一种高效的铁(III)氯化物促进的α,β-炔基对甲苯磺酰腙与二硒醚之间的环化反应，形成 4-(芳基硒基)-1H-吡唑骨架。该反应通过使用廉价的铁(III)氯化物代替昂贵的过渡金属添加剂，在一步中形成 C-N 和 C-Se 键。该策略具有易于合成的底物、温和的反应条件和对官能团的高容忍度的特点。
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