天然产物治疗关节炎的方案。

Scenario of the Treatment of Arthritis with Natural Products.

机构信息

Department of Health Sciences, University of Sergipe, Sao Cristovao, Brazil.

Department of Pharmacy, University of Sergipe, Sao Cristovao, Brazil.

出版信息

Recent Pat Inflamm Allergy Drug Discov. 2020;14(2):95-105. doi: 10.2174/1872213X14666200228103001.

DOI:10.2174/1872213X14666200228103001

PMID:32108012

Abstract

BACKGROUND

Conventional treatments of arthritis use toxic and poorly tolerated drugs. Therefore, natural products are an alternative because they are important sources of bioactive substances with therapeutic potential.

OBJECTIVE

To perform synthesis of patent applications associated with the use of natural products in the technological development of the invention for use in treating arthritis.

METHODS

The search for patents was conducted using the following databases of World Intellectual Property Organization (WIPO), European Patent Office (EPO, Espacenet), United States Patents and Trademark Office (USPTO) and National Institute of Intellectual Property (INPI) using as keywords - arthritis, treatment and the International Patent Classification (IPC) A61K36 / 00.

RESULTS

A total of 617 patents related to the subject were registered in the period available in patents databases during the study period from the years 2005 to 2017, of which 44 were analyzed based on the established inclusion criteria. The most important countries for protecting these inventions were China, followed by the United States of America, the Republic of Korea and Japan. As for the typology of depositors, that were identified by Educational Institutions and Public Institutes of Research (IEIPP) and Companies and Private Research Institutes (EIPP).

CONCLUSION

The analysis of patents made it possible to characterize the natural products used in the treatment of arthritis, with emphasis on botanical extracts (71%), as a single component, as well as in association with other botanical extracts, isolated compounds and minerals.

摘要

背景

关节炎的常规治疗方法使用有毒且耐受性差的药物。因此，天然产物是一种替代方法，因为它们是具有治疗潜力的生物活性物质的重要来源。

目的

对与天然产物在关节炎治疗发明技术开发中应用相关的专利申请进行合成。

方法

使用世界知识产权组织（WIPO）、欧洲专利局（EPO，Espacenet）、美国专利商标局（USPTO）和国家知识产权研究所（INPI）的以下数据库，使用“关节炎、治疗和国际专利分类（IPC）A61K36/00”作为关键词进行专利搜索。

结果

在 2005 年至 2017 年研究期间，从专利数据库中可获得的时间段内，共登记了 617 项与该主题相关的专利，其中 44 项根据既定纳入标准进行了分析。在保护这些发明方面最重要的国家是中国，其次是美利坚合众国、大韩民国和日本。至于存款人的类型学，是由教育机构和公共研究所（IEIPP）以及公司和私人研究所（EIPP）确定的。