Kumarguru B N, Ramaswamy Anikode S, Shaik Shahanuma, Karri Aruna, Srinivas Venugopal Sandeep, Prashant B M
Department of Pathology, PES Institute of Medical Sciences and Research, Kuppam, Chittoor, Andhra Pradesh, India.
Consultant Pathologist, Ashwini Diagnostics, Pogathota, Nellore, Andhra Pradesh, India.
Indian J Pathol Microbiol. 2020 Feb;63(Supplement):S117-S122. doi: 10.4103/IJPM.IJPM_731_18.
Tumor budding denotes a phenomenon in which the tumor cells, singly or in small aggregates, become detached from the neoplastic glands at the invasive front of adenocarcinoma. Tumors with budding cells have a significantly more aggressive clinical course. Significance of tumor budding has mainly been examined in the field of colorectal cancer.
To document the number tumor buds at the invasive front of invasive breast cancer. To correlate the number of tumor buds with other histopathological parameters, and available clinical details.
Analytical study at a rural tertiary care referral institute.
It was a retrospective study of invasive breast cancer cases from January 2012 to April 2015. Tumor buds were counted in H and E stained sections in 10 High Power Fields (HPFs). Association of tumor budding with histological parameters and available clinical details were analyzed statistically.
Frequencies, Chi-Square Test and Crosstabs were used for calculation.
50 cases of invasive breast carcinoma were analyzed. Invasive ductal carcinoma constituted predominant histological type (92%). Low tumor budding (tumor buds ≤20/10HPFs) constituted 20 cases. High tumor budding (tumor buds >20/10HPFs) constituted 30 cases. Association of high tumor budding with lympho-vascular invasion, lymph node metastasis, primary tumor staging, regional lymph node staging, necrosis and Monckeberg medial sclerosis was statistically significant.
Tumor budding may be incorporated as a new parameter in reporting protocols. Tumor budding serves as an indispensable touchstone in evaluating cases of invasive breast cancer.
肿瘤芽生是指肿瘤细胞单个或小聚集从腺癌浸润前沿的肿瘤腺体脱离的现象。有芽生细胞的肿瘤临床病程明显更具侵袭性。肿瘤芽生的意义主要在结直肠癌领域进行了研究。
记录浸润性乳腺癌浸润前沿的肿瘤芽数量。将肿瘤芽数量与其他组织病理学参数及可用的临床细节相关联。
在一家农村三级医疗转诊机构进行的分析性研究。
这是一项对2012年1月至2015年4月浸润性乳腺癌病例的回顾性研究。在苏木精和伊红染色切片的10个高倍视野（HPF）中计数肿瘤芽。对肿瘤芽生与组织学参数及可用临床细节的关联进行统计学分析。
使用频率、卡方检验和交叉表进行计算。
分析了50例浸润性乳腺癌病例。浸润性导管癌是主要的组织学类型（92%）。低肿瘤芽生（肿瘤芽≤20/10HPF）有20例。高肿瘤芽生（肿瘤芽>20/10HPF）有30例。高肿瘤芽生与淋巴管侵犯、淋巴结转移、原发肿瘤分期、区域淋巴结分期、坏死和蒙克贝格中膜硬化的关联具有统计学意义。
肿瘤芽生可作为报告方案中的一个新参数纳入。肿瘤芽生是评估浸润性乳腺癌病例不可或缺的试金石。
