Department of Obstetrics and Gynecology, School of Medical Sciences, University of Campinas, UNICAMP, Campinas, São Paulo, Brazil.
Menopause. 2020 May;27(5):519-525. doi: 10.1097/GME.0000000000001501.
The aim of the study was to evaluate the efficacy of interferential current (IC) in the sexual function of women with premature ovarian insufficiency (POI) using systemic hormone therapy (HT), compared to topical estriol.
A randomized clinical trial with 40 women with POI using systemic HT, who were sexually active and referred for dyspareunia and reduction of lubrication. The women were divided into two treatment groups for 4 weeks: IC group (eight electrotherapy sessions twice a week); or E group (estriol vaginal cream, daily application, 0.5 mg/d). The Female Sexual Function Index was used to evaluate pre-/posttreatment sexual function.
Mean age was 37.13 ± 7.27 years and mean treatment time with HT was 8.20 ± 8.73 years, similar data for both groups. There was an improvement in global sexual function, lubrication, and pain domains for both treatments. The differences between the pre-/posttreatment lubrication scores were respectively 0.75 ± 3.31 (P = 0.014) for IC and 1.16 ± 1.22 (P < 0.001) for estriol, whereas for dyspareunia the differences were 1.00 ± 1.47 (P = 0.005) for IC, and 0.68 ± 1.30 (P = 0.006) for estriol. There was no pre-/posttreatment difference for the desire and arousal domains. Only in the IC group did orgasm (difference 0.90 ± 1.42, P = 0.010) and satisfaction improve (difference 0.70 ± 1.28, P = 0.021).
The use of perineal IC seems to be a new option for women with POI using systemic HT and presenting with sexual complaints, leading to an improvement in pain, lubrication, satisfaction, and orgasm.
本研究旨在评估经皮电神经刺激（IC）对接受全身激素治疗（HT）的卵巢早衰（POI）女性性功能的疗效，与局部雌三醇进行比较。
一项随机临床试验纳入了 40 名 POI 女性患者，她们正在接受全身 HT，有性生活，存在性交困难和阴道干燥等问题。这些女性被分为两组，分别接受为期 4 周的治疗：IC 组（8 次电疗，每周两次）；或 E 组（雌三醇阴道乳膏，每日一次，0.5mg/d）。采用女性性功能指数评估治疗前后的性功能。
平均年龄为 37.13±7.27 岁，HT 治疗时间平均为 8.20±8.73 年，两组数据相似。两种治疗方法均能改善整体性功能、润滑度和疼痛领域。治疗前后的润滑度评分差异分别为 IC 组 0.75±3.31（P=0.014）和雌三醇组 1.16±1.22（P<0.001），而性交困难的评分差异分别为 IC 组 1.00±1.47（P=0.005）和雌三醇组 0.68±1.30（P=0.006）。在欲望和唤起领域，治疗前后没有差异。只有在 IC 组，性高潮（差异 0.90±1.42，P=0.010）和满意度（差异 0.70±1.28，P=0.021）得到改善。
对于接受全身 HT 治疗且存在性抱怨的 POI 女性，使用经皮 IC 似乎是一种新的选择，可改善疼痛、润滑度、满意度和性高潮。
